Table 2

Highly differentiated functional SNPs with F_ST ranking top 1% of all autosomal SNPs (empirical p<0.01)

rsID	Gene	F_ST	f_CHB	f_HUI	f_KGZ	f_KZK	f_UIG	f_TJK	f_CEU	Function	Type	Substrate
rs2235047	ABCB1	0.235	0.500	0.383	0.207	0.278	0.119	0.075	0.008	Intron	NF_ASS	Anthracyclines
rs2470890	CYP1A2	0.225	0.118	0.250	0.196	0.267	0.262	0.170	0.656	Synonymous	NF_ASS	Paroxetine
rs1799929	NAT2	0.157	0.023	0.033	0.087	0.111	0.333	0.160	0.410	Synonymous	NF_ASS	Isoniazid
rs1208	NAT2	0.133	0.023	0.067	0.120	0.100	0.310	0.266	0.399	Non-synonymous	F_AAS	Isoniazid
rs4148323	UGT1A9	0.107	0.214	0.183	0.141	0.244	0.143	0.011	0.000	Non-synonymous	NF_ASS	Irinotecan
rs17822931	ABCC11	0.479	0.107	0.966	0.900	0.717	0.589	0.255	0.417	Non-synonymous	F_NAS	–
rs2066714	ABCA1	0.238	0.869	0.275	0.233	0.576	0.556	0.692	0.548	Non-synonymous	F_NAS	–
rs1056836	CYP1B1	0.125	0.522	0.921	0.800	0.826	0.733	0.819	0.810	Non-synonymous	F_ASS	Taxanes
rs12418	CHST3	0.112	0.489	0.101	0.183	0.196	0.378	0.223	0.238	3′_UTR	NF_ASS	Docetaxel
rs4148945	CHST3	0.108	0.486	0.101	0.200	0.196	0.378	0.234	0.238	3′_UTR	NF_ASS	Docetaxel