Regression coefficient (95% CI) | ||
---|---|---|
Cohort | MS vs MM | MZ vs MM† |
BO | 2.31 (−0.24 to 4.86) | 7.33** (2.36 to 12.30) |
CaPS | 0.27 (−0.97 to 1.51) | 0.55 (−1.08 to 2.18) |
ELSA | 0.20 (−0.40 to 0.81) | 2.02**** (1.12 to 2.92) |
HAS | 0.24 (−3.04 to 3.51) | −0.26 (−3.69 to 3.18) |
HCS | −0.10 (−0.87 to 0.67) | 1.23* (0.09 to 2.37) |
LBC1921 | 0.44 (−1.55 to 2.43) | 1.06 (−1.89 to 4.00) |
NSHD | 0.68 (−0.11 to 1.47) | 1.84** (0.64 to 3.04) |
WHII | 0.23 (−0.34 to 0.81) | 1.24** (0.34 to 2.14) |
Combined FE | 0.28 (−0.03 to 0.59) | 1.50**** (1.03 to 1.97) |
Combined RE | 0.28 (−0.03 to 0.59) | 1.51**** (1.04 to 1.97) |
Estimated var‡ | 2.77e−13 (1.06e−26 to 7.27e+00) | 1.67e−12 (1.59e−25 to 1.76e+01) |
Estimates for PI-SS, SZ and ZZ are provided in the online supplement.
*p<0.05, **p<0.01, ***p<0.001, ****p<0.0001.
†Exact p values for PI-MZ—height were 3.6×10−10 (FE) and 2.9×10−10 (RE).
‡Estimated variance of the random slope on carrier status modelled by the RE model.
BO, Boyd Orr; CaPS, Caerphilly Prospective Study; ELSA, English Longitudinal Study of Ageing; FE, fixed effect; HAS; Hertfordshire Ageing Study; HCS, Hertfordshire Cohort Study; LBC1921, Lothian Birth Cohort 1921; NSHD, MRC National Survey of Health and Development; RE, random effect; WHII, Whitehall II Study.