Checklist for reporting of prophylactic gastrectomy specimens
| 1. Features of ≥pT1b carcinoma(s) | Growth pattern (diffuse infiltration vs localised tumour) Anatomic location (cardia, fundus, body, transitional zone, antrum) Measurements Histological type according to WHO89 and Laurén's90 classifications Lymphatic, venous and neural invasion (present or absent) Tumour, node, metastases stage |
| 2. Features of intramucosal precursor lesions and pT1a SRCC | Number of lesions Anatomic location (cardia, fundus, body, transitional zone, antrum) Measurements Aggressive features: pleomorphism, loss of mucin, spindle cells, small cells, mitoses Stromal reaction related to lesions: desmoplasia; lymphocytic, eosinophilic or granulomatous inflammatory reaction Surgical margin status (proximal oesophageal, distal duodenal mucosa, including donuts), to confirm there is no residual gastric mucosa and no tumour at margins. Lymph node status |
| 3. Non-neoplastic mucosa: changes more commonly seen in this condition | Tufting/hyperplastic mucosal changes Surface epithelial vacuolisation Globoid change |
| 4. Other findings in surrounding mucosa | Inflammation (acute, chronic, erosion, ulceration) Helicobacter pylori Intraepithelial lymphocytes Lymphoid infiltrates Glandular atrophy Intestinal metaplasia Adenomatous dysplasia |
SRCC, signet ring cell carcinoma.