Table 1

Methotrexate (MTX) sensitivity of double minute (DM)-containing and homogeneously staining region (HSR)-containing cells, with or without DNA-PKcs depletion

CellIC50 (mM)Fold change
DM-containing control0.049195
shDNA-PKcs 10.0101744.8
shDNA-PKcs 20.0055788.8
HSR-containing control0.014116
shDNA-PKcs 10.0139801.0
shDNA-PKcs 20.0069822.0