Author/year | Type of lymphoma | Gene defect | Age (years) | Chemotherapy | Other therapy | Response | Outcome/status |
---|---|---|---|---|---|---|---|
Ostergaard/2005 | T cell NHL | MSH6 | 10 | Yes | No | Partial remission | Died from progression 6 months later |
Scott/2007 | T cell NHL | MSH2 | 2.5 | BFM-NHL95 & MRC ALL 97/99 | No | Partial remission | Recurrence 2 weeks after completion of chemotherapy |
2.5 | MRC ALL R3 protocol (minus cyclophosphamide) etoposide | Total body RT, peripheral blood stem cell transplantation | Complete remission | Alive, 6 years | |||
Kratz/2008 | T cell NHL | PMS2 | 6 | BFM-NHL95 | No | Complete remission | Alive, 16 years |
Kruger/2008 | T cell NHL | PMS2 | 10 | Euro-LB 02 | No | Complete remission | Alive |
Peters/2009 | T cell NHL | MSH6 | 8 | Children's oncology group protocol A 5971 | No | Complete remission | Relapse 9 months after diagnosis |
8–9 | ifosfamide, cisplatin, etoposide, nelarabine | Radiotherapy | Resistant | Progression, died at age 9 years | |||
Ripperger/2010 | T cell NHL | MSH6 | 6 | BFM-NHL95 | No | Not specified | Relapse 6 months after completion of chemotherapy |
ALL REZ BFM 2002 | Haematopoietic stem cell transplantation | Complete remission | Alive 7 years later | ||||
Ilencikova/2011 | T cell NHL | MSH6 | 11 | Euro-LB 2002 | Good response | Died from BT <1 year | |
Baas/2013 | T cell NHL | MLH1 | 5.5 | Children's oncology group-A5971 | No | Died from staphylococcal sepsis | |
Baas/2013 | B cell NHL | PMS2 | 9 | SNWLK-94 | No | Complete remission | 11years, 6 months: T cell NHL |
Euro LB-02 protocol | No | Not reported | |||||
Baas/2013 | T cell NHL | PMS2 | 5.5 | Euro LB-02 | No | “Initially good response” | Died 9 months later from sepsis during bone marrow aplasia |
ALL, acute lymphoblastic leukaemia; CMMR-D, constitutional mismatch repair-deficiency; NHL, non-Hodgkin lymphoma.