Biometrics of leucocyte telomere length dynamics
| LTL | Corr. MZ | Corr. DZ | Heritability | Dominant genetic | Shared environ. | Individual environ. | Log Lik. | AIC | p Value |
|---|---|---|---|---|---|---|---|---|---|
| Baseline examination | |||||||||
| Saturated | 0.85 | 0.53 | |||||||
| ACE* | 0.86 | 0.54 | 0.64 (0.39 to 0.83) | 0 | 0.22 (0.06 to 0.49) | 0.14 (0.11 to 0.18) | −414 | 837 | |
| ADE | 0.86 | 0.43 | 0.86 (0.81 to 0.89) | 0.0 (−, −) | 0 | 0.14 (0.11 to 0.18) | −414 | 840 | |
| AE | 0.86 | 0.43 | 0.86 (0.81 to 0.89) | 0 | 0 | 0.14 (0.11 to 0.18) | −414 | 838 | 0.08 |
| CE | 0.7 | 0.7 | 0 | 0 | 0.7 | 0.29 | −435 | 881 | 0 |
| Follow-up examination | |||||||||
| Saturated | 0.87 | 0.63 | −363 | 737 | |||||
| ACE* | 0.87 | 0.63 | 0.46 (0.28 to 0.66) | 0 | 0.40 (0.22 to 0.60) | 0.13 (0.10 to 0.17) | −363 | 737 | |
| ADE | 0.87 | 0.43 | 0.86 (−, −) | 0.0 (−, −) | 0 | 0.13 (0.10 to 0.17) | −368 | 748 | |
| AE | 0.87 | 0.43 | 0.87 (0.83 to 0.90) | 0 | 0 | 0.13 (0.10 to 0.17) | −368 | 746 | 0 |
| CE | 0.76 | 0.76 | 0 | 0 | 0.76 (0.70 to 0.81) | 0.24 (0.19 to 0.29) | −379 | 768 | 0 |
| Follow-up vs baseline examinations | |||||||||
| Saturated | 0.31 | 0.19 | 208 | −407 | |||||
| ACE | 0.31 | 0.19 | 0.24 (0.02 to 0.79) | 0 | 0.07 (0.00 to 0.92) | 0.68 (0.53 to 0.82) | 208 | −407 | |
| ADE | 0.32 | 0.16 | 0.32 (0.20 to 0.47) | 0.0 (–, –) | 0 | 0.68 (0.53 to 0.80) | 208 | −407 | |
| AE* | 0.32 | 0.16 | 0.32 (0.20 to 0.47) | 0 | 0 | 0.68 (0.53 to 0.80) | 208 | −409 | 0.71 |
| CE | 0.26 | 0.26 | 0 | 0 | 0.26 (0.16 to 0.39) | 0.74 (0.61 to 0.84) | 208 | −408 | 0.29 |
| LTL attrition rate | |||||||||
| Saturated | 0.28 | 0.14 | 184 | −361 | |||||
| ACE | 0.28 | 0.14 | 0.28 (0.03 to 0.80) | 0 | 0.0 (−, −) | 0.72 | 184 | −361 | |
| ADE | 0.28 | 0.14 | 0.27 (0.16 to 0.44) | 0.0 (−, −) | 0 | 0.72 (0.56 to 0.84) | 184 | −361 | |
| AE* | 0.28 | 0.14 | 0.28 (0.16 to 0.44) | 0 | 0 | 0.72 (0.56 to 0.84) | 184 | −363 | 0.99 |
| CE | 0.21 | 0.21 | 0 | 0 | 0.21 (0.11 to 0.35) | 0.79 (0.64 to 0.89) | 184 | −362 | 0.25 |
Biometric models for level of leucocyte telomere length (LTL) at (1) baseline examination, (2) follow-up examination and LTL attrition rate, (3) follow-up adjusted for baseline and (4) difference over follow-up time.
*Best fitting and most parsimonious model.
ACE, additive genetic and shared plus unique environmental components; ADE, additive plus dominant genetic and individually unique environmental components; AE, sub-model of ACE with zero shared environmental component; AIC, Akaike Information Index; CE, sub-model of ACE with zero genetic component; p for no genetic component (A=0) and no shared environmental component (C=0) as sub-models of ACE; Corr., correlations; Dominant genetic, dominant genetic effect; DZ, dizygotic twins; individual environ., individually unique environmental effect; LTL, leucocytes telomere length; MZ, monozygotic twins; numbers in parentheses=95% CIs; saturated model—equal mean and variance for MZ and DZ twins; shared environ., shared environmental effect.