Additional examples of birth cohorts with the capacity to explore non-genetic transgenerational effects in humans (see text)
| Cohort name | Participant number* | General description | Reference |
|---|---|---|---|
| ABC | 106 370 | The Aarhas Birth cohort Denmark has collected data during pregnancy and delivery for women since 1989. The associated biobank was established in 2008 to provide the opportunity to investigate the role of genetic factors, environmental exposures and lifestyles in pregnancy on the risk of disease in the offspring. | 102 |
| ABIS | 17 045 | All Babies in Southeast Sweden (ABIS) is a retrospective birth cohort of 17 055 children born October 1997–October 1999. Parental and child questionnaire follow-up. Extensive biobank with repeated sampling at follow up. | † |
| ALSPAC | 14 541 | The Avon Longitudinal Study of Parents and Children recruited 14 541 pregnant women with due date April 1991–December 1992. Information on parents’ life taken during study pregnancy. Mothers and children have been followed using questionnaires. Children have been followed at regular clinical assessment visits. Extensive biobank. | 103 |
| BCS70 | 17 000 | The British Cohort Study follows people born in the UK in a single week of 1970. It has collected information on health, physical, educational and social development, among other factors. | 104 |
| BIB | 13 776 | Born in Bradford is a longitudinal birth cohort study aimed at recruit a multiethnic cohort of babies born in Bradford (UK) and their parents in order to investigate fetal growth, birth and long-term outcomes by ethnic groups. | 105 |
| DNBC | 94 837 | The Danish National Birth Cohort recruited pregnant women and their children from 1996 to 2002. Multiple interview data and biospecimens were collected including food frequency questionnaire in gestational week 24 and periconceptional use of medicine and food supplements. Data for the cohort are collected at regular times from hospital discharge registry and other national registers. | 106 |
| MCS | 19 000 | The Millennium Cohort Study follows the lives of children born in the UK in 2000–2001. It collects information on siblings and parents covering topics including socioeconomic variables, behaviour and cognitive development. | 107 |
| MOBA | 108 500 | The Norwegian Mothers and Babies study aims to quantify the influence of various social, genetic, nutritional and environmental exposures on pregnancy outcomes and child health. Data and biospecimens were collected in pregnancy and at birth. Fathers were also recruited and provided blood. Health outcomes were collected from hospital discharge registries as well as other health registries such as the Medical Birth Registry, the Cancer Registry and the Diabetes Registry. | 108 |
| NCDS | 17 000 | The National Child Development Study (1958 birth cohort study) follows the lives of children born in the UK in a single week of 1958. It has collected information on physical and educational development, economic circumstances, employment, family life and health behaviour among other variables. DNA bank. | 109 |
| UBCoS Multigen | 7567 | Uppsala Birth Cohort Multigenerational Study exploring several issues highly relevant for health equity research. Life-course approach to analysis detailed biological and social data stretching from birth to old age with access to more than two successive generations. | 110 |
*Only those with >10 000 participants or a focus on multigenerational studies are included.
†http://www.abis-studien.se/hem/english-11100423. Further information from the European cohort available at http://www.birthcohorts.net/.