Above-threshold SCQ scores in male and female RASopathy subjects and healthy siblings
| Males/females | Males with SCQ≥15 (%) | Females with SCQ≥15 (%) | OR | p Value | |
|---|---|---|---|---|---|
| All RASopathies | 102/109 | 39 (38) | 18 (17) | 3.1 | 0.0003 |
| NF1 | 26/40 | 7 (27) | 0 (0) | – | 0.0008 |
| CS | 22/21 | 8 (36) | 3 (14) | 3.4 | 0.095 |
| NS | 26/22 | 6 (23) | 4 (18) | 1.4 | 0.48 |
| CFC | 28/26 | 18 (64) | 11 (42) | 2.5 | 0.0891 |
| Siblings | 66/51 | 0 (0) | 0 (0) | – | 1.0 |
The percentage of males and females within each group who scored 15 or higher on the SCQ are shown. OR=Odds Ratio showing male compared with female prevalence. One-tailed Fisher's Exact test p values are calculated as shown.
CFC, cardio-facio-cutaneous syndrome; CS, Costello syndrome; NF1, neurofibromatosis type 1; NS, Noonan syndrome; SCQ, Social Communication Questionnaire.