Occurrence of clinically atypical nevi in families with CDK4 germline mutations
| CDK4 positive family members | |||||
|---|---|---|---|---|---|
| CDK4 negative family members | Affected | Unaffected | |||
| Clinically atypical nevi* | N=49 (%) | N=50 (%) | p Value† | N=20 (%) | p Value† |
| Present | 13 (26.5) | 35 (70.0) | <0.001 | 15 (75.0) | <0.001 |
| Not present | 36 (73.5) | 15 (30.0) | 5 (25.0) | ||
*Data on CDK4 mutation status and clinically atypical nevi were available for 119 subjects.
†CDK4 negative family members were compared with affected and with unaffected CDK4 positive family members, respectively.