Outcomes | Baseline | Follow-up | Mean difference Follow-up–baseline | Effect size | p Value | |||
---|---|---|---|---|---|---|---|---|
Awaiting PGx | Received PGx | Awaiting PGx | Received PGx | Awaiting PGx | Received PGx | |||
Primary outcomes | ||||||||
Visits to physician (Mean, SD) | 3.6 (3.9) | 3.4 (3.4) | 3.5 (3.4) | 3.7 (3.8) | −0.04 (3.7) | 0.36 (3.5) | η2=0.003 | 0.04* |
Follow-up state anxiety (Mean, SD) | 34.8 (9.4) | 35.4 (9.7) | 33.8 (9.8) | 34.9 (10.3) | −1.03 (6.7) | −0.42 (7.0) | η2=0.002 | 0.10* |
Share results with physician (% Yes) | NA | NA | 37.0 | 44.4 | NA | NA | OR=1.50 | 0.001† |
Secondary outcomes | ||||||||
Physician ordered additional tests‡ (% yes) | NA | NA | 17.0 | 26.9 | NA | NA | OR=1.74 | 0.01† |
Visits to other healthcare provider (Mean, SD) | NA | NA | 1.2 (2.6) | 1.4 (3.3) | NA | NA | η2=0.001 | 0.22 |
Share results with genetic counselor (% Yes) | NA | NA | 11.5 | 18.7 | NA | NA | OR=1.84 | <0.0005† |
Follow-up test-related distress (Mean, SD) | NA | NA | 1.2 (4.3) | 1.0 (4.2) | NA | NA | η2<0.0005 | 0.67§ |
*Repeated measures analysis of variance, time by group interaction.
†Logistic regression, effect of group (PGx recipient coded 1, non-recipient coded 0).
‡Analysis included the subset of individuals who reported sharing their results with a physician (n=523).
§Analysis of covariance, effect of group.