Case ID | Patient ID | Mutation or variant | N | Clinical information and gross morphology | Pathologist 1 | Pathologist 2 |
MoCa57 | 428 | p.[V319I;G487E];[V319I;C399Y] | 2 | GA 22 weeks. SB of a morphologically normal male fetus, baby weight 465 g, 27 cm length, placenta 10×10 cm, 163 g, cord inserted centrally and measures 11 cm. No histopathology done on the baby. The patient had vaginal spotting since 10 weeks, high βHCG 160 ,625 U/l, vaginal infection, antibiotic treatment, bleeding again around 21 weeks, lower abdominal pain few days before the stillbirth and was admitted to the hospital. Placenta removed manually | Immature placenta, mild chorioamnionitis, decidual necrosis | Chorionitis, subchorionic haemorrhage |
4 | GA 28 1/7 weeks, male live birth. True knot. Cervical incompetence, complete microbiology workout negative, cerclage, bed rest, and antibiotic treatment. Preterm labour and rupture of membranes. Chorioamnionitis. Caesarean section. Accessory lobe. The baby was later diagnosed with several congenital malformations described in Patients and Methods | Immature placenta, marked chorioamnionitis, surface vasculitis, funisitis, deciduitis; mural thrombosis of surface vessels | Advanced villous maturation, acute vasculitis and funisitis. Severe acute chorioamnionitis and deciduitis | |||
MoCa209 | 804 | p.[V319I(;) R156Q] | 2 | GA 40 6/7 weeks, 3.3 kg female, 615 g, 18×14×2.5, cord 30 cm, 3 vessels | Normal | Normal |
2 | GA 39 3/7 weeks, 530 g, 17×16×3 cm, cord 44 cm, 3 vessels, false knot | Normal | Normal | |||
MoCa182 | 754 | p.[A481T];[=] | 1 | Live birth of a girl | Normal placenta with minimal necrosis of decidua | Dysmature stem villi and mild chorangiosis |
MoCa207 | 802 | p.[G487E];[=] | 2 | GA 41 weeks, 824 g | Chorangiomas in the surface near the insertion of the cord | Prominent perivillous fibrin aggregates, chorangiosis |
MoCa210 | 806 | p.[V319I(;) A481T] | 1 | GA 35 1/7 weeks, spontaneous vaginal delivery of a male baby, 720 g, 21×18.5×2.8, 76 cm, 1.4 cm, cord twisted, one knot, 3 vessels eccentrically | Normal | Chorangiotic changes identified |
MoCa186 | 758 | p.[V319I;G487E];[V319I;G487E]; [F250L(;)A481T] | 3 | GA 40 5/7 weeks, birth weight 3670 g, female, spontaneous vaginal delivery, placenta 20×20, cord 50 cm with 3 vessels, central insertion | Very minimal chorangiosis and focal decidual necrosis | Chorangiotic changes identified, subamniotic cyst |
2 | GA 38 2/7 weeks, birth weight 4045 g, placenta weight 650 g, cord 53 cm and 1.2 cm, 3 vessels | Minimal chorangiosis and mild chorioamnionitis | Oedematous and dysmature stem villi, chorangiosis |
Abnormal features are underlined.
N, number of available histopathology blocks and slides; GA, gestational age; HCG, human chorionic gonadotrophin; SB, stillbirth.