Table 3

Summary of histopathological evaluations of the placentas of patients with NLRP7 mutations and at least one rare non-synonymous variant

Case ID	Patient ID	Mutation or variant	N	Clinical information and gross morphology	Pathologist 1	Pathologist 2
MoCa57	428	p.[V319I;G487E];[V319I;C399Y]	2	GA 22 weeks. SB of a morphologically normal male fetus, baby weight 465 g, 27 cm length, placenta 10×10 cm, 163 g, cord inserted centrally and measures 11 cm. No histopathology done on the baby. The patient had vaginal spotting since 10 weeks, high βHCG 160 ,625 U/l, vaginal infection, antibiotic treatment, bleeding again around 21 weeks, lower abdominal pain few days before the stillbirth and was admitted to the hospital. Placenta removed manually	Immature placenta, mild chorioamnionitis, decidual necrosis	Chorionitis, subchorionic haemorrhage
MoCa57	428	p.[V319I;G487E];[V319I;C399Y]	4	GA 28 1/7 weeks, male live birth. True knot. Cervical incompetence, complete microbiology workout negative, cerclage, bed rest, and antibiotic treatment. Preterm labour and rupture of membranes. Chorioamnionitis. Caesarean section. Accessory lobe. The baby was later diagnosed with several congenital malformations described in Patients and Methods	Immature placenta, marked chorioamnionitis, surface vasculitis, funisitis, deciduitis; mural thrombosis of surface vessels	Advanced villous maturation, acute vasculitis and funisitis. Severe acute chorioamnionitis and deciduitis
MoCa209	804	p.[V319I(;) R156Q]	2	GA 40 6/7 weeks, 3.3 kg female, 615 g, 18×14×2.5, cord 30 cm, 3 vessels	Normal	Normal
MoCa209	804	p.[V319I(;) R156Q]	2	GA 39 3/7 weeks, 530 g, 17×16×3 cm, cord 44 cm, 3 vessels, false knot	Normal	Normal
MoCa182	754	p.[A481T];[=]	1	Live birth of a girl	Normal placenta with minimal necrosis of decidua	Dysmature stem villi and mild chorangiosis
MoCa207	802	p.[G487E];[=]	2	GA 41 weeks, 824 g	Chorangiomas in the surface near the insertion of the cord	Prominent perivillous fibrin aggregates, chorangiosis
MoCa210	806	p.[V319I(;) A481T]	1	GA 35 1/7 weeks, spontaneous vaginal delivery of a male baby, 720 g, 21×18.5×2.8, 76 cm, 1.4 cm, cord twisted, one knot, 3 vessels eccentrically	Normal	Chorangiotic changes identified
MoCa186	758	p.[V319I;G487E];[V319I;G487E]; [F250L(;)A481T]	3	GA 40 5/7 weeks, birth weight 3670 g, female, spontaneous vaginal delivery, placenta 20×20, cord 50 cm with 3 vessels, central insertion	Very minimal chorangiosis and focal decidual necrosis	Chorangiotic changes identified, subamniotic cyst
MoCa186	758	p.[V319I;G487E];[V319I;G487E]; [F250L(;)A481T]	2	GA 38 2/7 weeks, birth weight 4045 g, placenta weight 650 g, cord 53 cm and 1.2 cm, 3 vessels	Minimal chorangiosis and mild chorioamnionitis	Oedematous and dysmature stem villi, chorangiosis

Abnormal features are underlined.
N, number of available histopathology blocks and slides; GA, gestational age; HCG, human chorionic gonadotrophin; SB, stillbirth.