Table 2

Reproductive fitness in a sample of adults with 22q11.2 deletion syndrome and their unaffected siblings

	22q11.2 deletion syndrome					Unaffected siblings					Analyses
	Total	Childless subjects		Live born offspring		Total	Childless subjects		Live born offspring		Childlessness^*		Live born offspring^†		Relative fitness^‡
	n	n	(%)	Max	Mean	n	n	(%)	Max	Mean	χ²	p Value	H	p Value
All subjects	141	121	(85.8)	4	0.2624	200	111	(55.5)	5	0.9250	34.9	<0.0001	35.4	<0.0001	0.2837
Males	70	66	(94.3)	2	0.1000	96	56	(58.3)	4	0.8438	26.9	<0.0001	26.4	<0.0001	0.1185
Females	71	55	(77.5)	4	0.4225	104	55	(52.9)	5	1.0000	10.9	0.0010	11.7	0.0006	0.4225
Subgroup with completed fertility
All subjects	33	24	(72.7)	4	0.6364	48	15	(31.2)	5	1.5208	13.5	0.0002	10.9	0.0010	0.4185
Males	16	13	(81.2)	2	0.3125	27	10	(37.0)	4	1.4444	^§	0.0103	8.4	0.0037	0.2164
Females	17	11	(64.7)	4	0.9412	21	5	(23.8)	5	1.6190	^§	0.0201	3.4	0.0671	0.5814
Subgroup with neither mental retardation nor schizophrenia
All subjects	53	37	(69.8)	4	0.5472	195	108	(55.4)	5	0.9333	3.6	0.0588	4.3	0.0377	0.5863
Males	27	23	(85.2)	2	0.2593	95	56	(58.9)	4	0.8421	^§	0.0123	6.3	0.0118	0.3079
Females	26	14	(53.8)	4	0.8462	100	52	(52.0)	5	1.0200	<0.1	0.8666	0.2	0.6229	0.8296

↵* Pearson's χ² test.
↵† Kruskal–Wallis test.
↵‡ In the absence of age differences, defined as a simple ratio of mean numbers of liveborn offspring in 22q11.2DS compared to the corresponding unaffected sibling mean; the latter therefore has a relative fitness set at 1.0.
↵§ Fisher's exact test.