Table 2

Association of the SNP rs716508 and hand OA in replication samples

rs716508
MAFβ (SE)p Value
Chingford study0.31−0.18 (0.06)0.004
CSAS0.29−0.25 (0.10)0.009
GARP study0.33−0.10 (0.08)0.20
Rotterdam study (rss)0.34−0.08 (0.04)0.07
Meta-analysis−0.12 (0.03)1.81×10−5
  • β, regression coefficient; Chr, chromosome; CSAS, Chuvasha Skeletal Aging Study; GARP, Genetics, Arthrosis, and Progression; MAF, minor allele frequency; rss, replication subset; SNP, single-nucleotide polymorphism.