| Study* | Gender | Ethnicity | IQ | Concomitant medications† | Fenobam dose (mg) | Side effects‡ | PPI§ | Type of improvement noted clinically‡ |
| 01-001 | M | C | 53 | Aripiprazole quetiapine | 50 | None | + | Improved eye contact and interaction |
| 01-002 | M | C | 55 | Venlafaxine aripiprazole | 150 | None | + | Improved interaction |
| 01-003 | F | AA/H | 85 | Venlafaxine | 150 | Mild sedation | – | No improvement |
| 01-004 | M | C | 52 | None | 150 | Mild sedation | – | Calmed behaviour, improved eye contact, less perseveration |
| 01-005 | F | C | 71 | None | 150 | None | + | Improved interaction |
| 01-006 | F | C | 66 | None | 150 | Mild sedation | – | Calmed behaviour, less nervous giggling, improved eye contact |
| 02-001 | M | C | N/A | None | 100 | None | – | Improved eye contact |
| 02-002 | F | C | 54 | Dextro-amphetamine fluoxetine | 50 | None | + | Calmed behaviour and improved eye contact |
| 02-003 | F | C | 53 | Methylphenidate | 100 | None | + | No improvement |
| 02-004 | M | C | 36 | Fluoxetine | 150 | None | + | Improved eye contact and interaction |
| 02-005 | M | AA | 36 | Dextro-amphetamine | 150 | None | – | No improvement |
| 02-006 | F | C | 50 | Escitalopram | 150 | Anxious, tremulous, clammy. Lightheaded when IV was put in | – | Calmed behaviour, able to tolerate blood draws better, much more tolerant of IV placement |
| Average (SD) | 55.5 (13.6) | |||||||
| range | 36–85 |
AA, African American; C, Caucasian; F, female; H, Hispanic; IV, intravenous catheter; M, male; N/A, IQ measurements were not available for this subject.
*01 = MIND Institute UCDMC; 02 = Rush University Medical Center.
†Only psychoactive concomitant medications; 3 subjects on stimulants, 3 on selective serotonin reuptake inhibitors, 2 on other antidepressant, 2 on atypical antipsychotics.
‡Side effects and clinical improvement were characterised by observations at designated time points (0,15, 30, 45, 60, 120, 180, 240, 300, 360 min) by the principal investigator (PI) and by formal questioning of the subject/guardian throughout the visit for the occurrence of central nervous system (CNS) side effects relevant to fenobam from a checklist (see Methods) new, or worsening of existing signs, symptoms or behaviours.
§Result of prepulse inhibition (PPI) after fenobam relative to baseline; “+” denotes achieved response criterion of 20% improvement in PPI and “–” represents <20% improvement.