Table 2

Two-point logarithm of odds (LOD) scores for chromosome 2 markers in two Han Chinese pedigrees with ankylosing spondylitis

Distance (cM)	Marker	Het	Family A LOD score					Family B LOD score					hLOD (α, θ)	p Value
			θ					θ
			0	0.1	0.2	0.3	0.4	0	0.1	0.2	0.3	0.4
215.25	D2S1371	0.78	−2.57	0.84	0.91	0.68	0.32	−1.14	0.57	0.51	0.33	0.11	3.27 (1.0, 0.2)	0.011
215.78	D2S1338	0.87	−2.92	0.84	0.91	0.68	0.32	0.53	0.44	0.33	0.21	0.09	2.95 (1.0, 0.1)	0.015
216.31	D2S2250	0.78	−2.78	0.84	0.91	0.68	0.32	2.14	1.71	1.25	0.78	0.31	5.87 (1.0, 0.1)	6.11E-04
218.45	D2S1242	0.88	0.39	1.75	1.47	1.02	0.48	2.38	1.96	1.49	0.97	0.44	8.54 (1.0, 0.1)	3.57E-05
220.59	D2S377	0.71	0.44	1.79	1.52	1.06	0.5	1.15	0.9	0.66	0.42	0.2	6.19 (1.0, 0.1)	4.32E-04
222.2	D2S102	0.86	2.28	1.88	1.44	0.95	0.42	1.03	0.81	0.59	0.38	0.18	7.62 (1.0, 0.0)	9.45E-05
222.73	D2S130	0.75	0.98	0.83	0.66	0.47	0.25	1.41	1.14	0.85	0.52	0.2	5.50 (1.0, 0.0)	9.08E-04
224.33	D2S2228	0.78	3.26	2.7	2.07	1.39	0.66	2.13	1.71	1.26	0.78	0.32	12.41 (1.0, 0.0)	6.29E-07
225.67	D2S2390	0.6	0.83	0.66	0.49	0.32	0.15	0.12	0.1	0.07	0.03	0.01	2.19 (1.0, 0.0)	3.70E-02
227.54	D2S2354	0.8	3.26	2.7	2.07	1.39	0.66	2.08	1.73	1.33	0.87	0.39	12.30 (1.0, 0.0)	7.08E-07
228.01	D2S1349	0.57	1.24	1.0	0.73	0.44	0.15	1.04	0.85	0.64	0.43	0.21	5.25 (1.0, 0.0)	1.19E-03
228.61	D2S159	0.77	0.85	0.67	0.49	0.31	0.14	0.63	0.49	0.35	0.2	0.09	3.41 (1.0, 0.0)	9.03E-03
229.14	D2S2158	0.77	2.59	2.23	1.75	1.2	0.59	2.08	1.73	1.33	0.87	0.39	10.75 (1.0, 0.0)	3.53E-06

All the LOD scores were evaluated at recombinant fraction from 0.0 to 0.4 with the penetrance of 0.56. The maximum heterogeneity LOD score was obtained at marker D2S2228.