Disorder | Lower age limit (years) | Examination | Interval (years) |
---|---|---|---|
CRC, colorectal cancer; MSI, microsatellite instability. | |||
*If gastric cancer runs in the family or in countries with a high incidence of gastric cancer. | |||
†If urinary tract cancer runs in the family. | |||
‡Amsterdam positive families. | |||
Lynch syndrome | 20–25 | Colonoscopy | 1–2 |
30–35 | Gynaecological examination, transvaginal ultrasound, aspiration biopsy | 1–2 | |
30–35 | Gastroduodenoscopy* | 1–2 | |
30–35 | Abdominal ultrasound, urinalysis and cytology urine† | 1–2 | |
Familial clustering of colorectal cancer without evidence of MSI‡ | 45–50 or 5–10 before age at diagnosis of first CRC in family | Colonoscopy | 3–5 |