The outcome of surveillance for endometrial cancer in families with Lynch syndrome
| UK/The Netherlands(Dove-Edwin et al,47 2002) | The Netherlands(Rijcken et al,48 2003) | Finland(Renkonen-Sinisalo et al,49 2006) | |
|---|---|---|---|
| –, not found; TVU, transvaginal ultrasound. | |||
| *Including one occult cancer detected at surgery. | |||
| Number of subjects | 269 | 41 | 175 |
| Mutation carriers | Not mentioned | 27% | 100% |
| Protocol | TVU | TVU | TVU and aspiration biopsy |
| Patient years of follow-up | 826 | 197 | 759 |
| Number of scans | 522 | 179 | 476 |
| Surveillance interval | 1–2 years | 1 year | 2–3 years |
| Premalignant lesions | — | 3 complex atypia | 5 complex atypia |
| Screen-detected cancer | — | — | 12* |
| Interval cancer | 2 | 1 | 2 |
| Figo I | 2 | 1 | 12 |
| Figo II | 1 | ||
| Figo III | 1 | ||