Tumours in autosomal dominant conditions
| Condition | Inheritance | Main tumours | Malignancies occurring post radiotherapy | Gene and chromosomal location |
|---|---|---|---|---|
| AD, autosomal dominant; BCC, basal cell carcinomas; MPNST, malignant peripheral nerve sheath tumours; VHL, von Hippel-Lindau disease. | ||||
| NF1 | AD | Neurofibroma, glioma, and MPNST | MPNST, glioma | NF1 -17q |
| NF2 | AD | Schwannoma, meningioma, ependymoma | MPNST | NF2 -22q |
| Gorlin | AD | BCC, medulloblastoma | BCC | PTCH -9q |
| VHL | AD | Renal cell carcinoma, retinal and cerebellar | ? | VHL -3p |
| haemangioblastoma | ||||
| Li-Fraumeni | AD | Sarcoma, breast cancer, glioma, lung cancer, | Sarcoma | TP53 -17p |
| syndrome | adreno-cortical tumours | |||