Levels of endoglin and ALK-1 in human umbilical vein endothelial cells of newborns from families with hereditary haemorrhagic telangiectasia (HHT)
| HHT type | Mutation status of neonate | n | Endoglin level (%) | n | ALK-1 level (%) | ||
|---|---|---|---|---|---|---|---|
| Median | Range (25–75%) | Median | Range (25–75%) | ||||
| *The distribution of endoglin levels in the group with ENG mutations was significantly different from all other groups. The two sided pair normal approximation was obtained from the two sample Wilcoxon test for comparison to the non-affected HHT1 group (p<0.001), while the t test was used for comparison to the groups with and without an ALK-1 mutation (p = 0.0002 in both cases). | |||||||
| †The distribution of ALK-1 levels for the group with an ALK-1 mutation was p = 0.03 (by t test) when compared with the combined HHT1 groups or with the last group (level of significance α = 0.01) | |||||||
| HHT1 | Yes (ENG) | 30 | 45.0* | 13.0 | 7 | 94.0 | 18.0 |
| HHT1 | None | 18 | 98.0 | 17.0 | 3 | 92.0 | 23.0 |
| HHT2 | Yes (ALK-1) | 8 | 98.5 | 25.5 | 4 | 60.5† | 24.5 |
| HHT2 | None | 6 | 106.5 | 31.0 | 3 | 96.0 | 3.0 |