Cancer risks for sites other than breast and ovary in BRCA2 mutation carriers
| ICD code | Location | Obs | Exp | RR | 95% CI | Pa (n) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| See Methods section for estimating RR. Obs, observed, exp, expected. | ||||||||||||
| – | All | 199 | 199.9 | 1 | 0.9 to 1.1 | 85 | ||||||
| 140–149 | Buccal cavity and pharynx | 6 | 3.6 | 2.4 | 0.9 to 5.3 | 4 | ||||||
| 141 | Tongue | 1 | 0.6 | 2.4 | 0.03 to 13.1 | 1 | ||||||
| 142 | Salivary glands | 1 | 0.4 | 4.6 | 0.1 to 25.4 | 1 | ||||||
| 143–145 | Mouth | 0 | 0.9 | – | – | – | ||||||
| 146–149 | Pharynx | 4 | 1.0 | 7.3 | 2.0 to 18.6 | 2 | ||||||
| 150–159 | Digestive system | 60 | 50.1 | 1.5 | 1.1 to 1.9 | 25 | ||||||
| 150 | Oesophagus | 1 | 2.0 | – | – | – | ||||||
| 151 | Stomach | 13 | 12.1 | 1.2 | 0.6 to 2.0 | 2 | ||||||
| 152 | Small intestine | 1 | 0.5 | 3.7 | 0.05 to 20.6 | – | ||||||
| 153 | Colon | 20 | 16.5 | 1.5 | 0.9 to 2.3 | 11 | ||||||
| 154 | Rectum | 3 | 10.8 | – | – | 2 | ||||||
| 153–154 | Colon/rectum | 23 | 27.2 | 0.7 | 0.4 to 1.0 | 13 | ||||||
| 155 | Liver | 5 | 0.9 | 10.9 | 3.5 to 25.4 | 2 | ||||||
| 156 | Gallbladder and extrahepatic bile duct | 1 | 2.8 | – | – | 1 | ||||||
| 157 | Pancreas | 14 | 4.4 | 5.9 | 3.2 to 10.0 | 7 | ||||||
| 160–165 | Respiratory system | 35 | 44.3 | 0.5 | 0.4 to 0.8 | 13 | ||||||
| 160 | Nasal cavaties | 0 | 0.4 | – | – | – | ||||||
| 161 | Larynx | 3 | 2.7 | 1.2 | 0.2 to 3.6 | 2 | ||||||
| 162 | Lung | 30 | 40.4 | 0.4 | 0.3 to 0.6 | 9 | ||||||
| 163 | Pleura/mesothelium | 0 | 0.6 | – | – | – | ||||||
| 170 | Bones | 3 | 0.4 | 14.4 | 2.9 to 42.1 | 1 | ||||||
| 171 | Connective tissues | 1 | 1.1 | 0.8 | 0.01 to 4.6 | 1 | ||||||
| 172 | Melanoma | 2 | 3.5 | 0.1 | 0.01 to 0.2 | 1 | ||||||
| 179–189 | Urogenital system | 43 | 40.5 | 1.2 | 0.8 to 1.6 | 20 | ||||||
| 180 | Cervix uteri | 1 | 2.5 | – | – | 1 | ||||||
| 182 | Corpus uteri | 6 | 4.4 | 1.8 | 0.7 to 3.9 | 3 | ||||||
| 185 | Prostate gland | 24 | 13.6 | 2.5 | 1.6 to 3.8 | 7 | ||||||
| 186 | Testis | 0 | 0.8 | – | – | – | ||||||
| 187 | Penis | 0 | 0.3 | – | – | – | ||||||
| 188 | Bladder | 9 | 8.4 | 1.2 | 0.5 to 2.3 | 6 | ||||||
| 189 | Kidney | 3 | 5.2 | 0.1 | 0.02 to 0.2 | 3 | ||||||
| 191 | Brain | 5 | 2.2 | 3.9 | 1.2 to 9.0 | 1 | ||||||
| 192 | Thyroid gland | 1 | 0.9 | 1.1 | 0.01 to 6.0 | – | ||||||
| 200–208 | Leukaemia and lymphoma | 8 | 12.4 | 0.2 | 0.1 to 0.4 | 5 | ||||||
| 200 | Non-Hodgkin’s disease | 3 | 4.9 | 0.2 | 0.03 to 0.4 | 2 | ||||||
| 201 | Hodgkin’s disease | 0 | 1.0 | – | – | – | ||||||
| 204–208 | Leukaemia | 5 | 4.1 | 1.5 | 0.5 to 3.5 | 3 | ||||||