Table 1

Phenotypic overlap of the cardiofaciocutaneous, Noonan and Costello syndromes

	CFC	Noonan syndrome¹¹	Costello syndrome^12,¹³
Head	Relative macrocephaly	Yes	Yes
	Dolichocephaly	Yes	No

Hair	Sparse, curly, friable	Curly	Fine, sparse, curly, kinky
	Absent eyebrows	No	No

Face	Tall forehead	Yes	No
	Narrowed temples	No	No
	Small chin	Yes	No

Eye	Palpebral ptosis	Yes	Yes
	Hypertelorism	Yes	No
	Downward-slanting palpebral fissures	Yes	Yes
	Epicanthal folds	Yes	Yes
	Exotropia	Strabismus	Strabismus

Ear	Earlobe creases	No	Fleshy lobes

Nose	Short	No	Yes
	Broad nasal base	No	Yes

Mouth	Deep philtrum	Yes	No
	Cupid’s bow lip	No	No