Mutations and SNPs identified in patients affected with acquired LQTS
| Gene | SNP* | Risk factor | Reference | Note |
|---|---|---|---|---|
| *NA, not available; SNP, single nucleotide polymorphism. | ||||
| LQT 1 gene (KvLQT1 | R555C | Terfenadine | Donger et al14 | Also linked to congenital LQTS |
| or KCNQ1) | Y315C | Cisapride | Napolitano et al15 | |
| Hypokalaemia | ||||
| R583C | Dofetilide | Yang et al16 | ||
| LQT2 gene (HERG | R328C | NA | Chevalier et al17 | |
| or KCNH2) | P347S | Cisapride | Piquette,18 Paulussen et al19 | |
| Clarithrommycin | ||||
| R784W | Amiodarone | Yang et al16 | ||
| LQT3 gene (SCN5A) | G615E | Quinidine | Yang et al16 | |
| L618F | Quinidine | Yang et al16 | ||
| S1103Y | NA | Chen et al,20 Splawski et al21 | Also linked to congenital arrhythmias | |
| R1193Q | Quinidine | Chen et al,1 Wang et al2 | Also linked to congenital LQTS | |
| Sotalol | ||||
| F1250L | Sotalol | Yang et al16 | ||
| V1667I | Halofantrine | Piippo et al22 | Also linked to congenital LQTS | |
| L1825P | Cisapride | Makita et al23 | ||
| LQT5 gene (KCNE1) | D85N | Sotalol | Paulussen et al19 | |
| Quinidine | ||||
| Hypokalaemia | ||||
| LQT6 gene (KCNE2) | T8A | Quinidine | Paulussen et al,19 Abbott et al,24 Sesti et al25 | |
| Amiodarone | ||||
| Sulfametoxazole | ||||
| Q9E | Clarithrommycin | Abbott et al24 | ||
| Hypokalaemia | ||||
| M54T | Procainamide | Sesti et al25 | ||
| I57T | Oxatomide | Sesti et al25 | ||
| A116V | Quinidine | Sesti et al25 | ||
| Mexiletine | ||||