Aspartyl proteases and their genetic disorders
| Gene | Protein | Disorder | Trans | Function | MIM | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| EOAD, early onset Alzheimer’s disease; AD, autosomal dominant; AR, autosomal recessive.; Trans, mode of transmission. | ||||||||||
| PRS1 | Presenilin 1 | EOAD | AD | Aβ generation | AD3 607822 | |||||
| PRS2 | Presenilin 2 | EOAD | AD | Aβ generation | AD4 600759 | |||||