Genotype distributions and allele frequencies of the examined PGC-1β variants in 7545 subjects with normal glucose tolerance, impaired glucose tolerance/impaired fasting glucose, and type 2 diabetes
| Type 2 diabetic patients (n = 1433) | Subjects with IFG + IGT (n = 1177) | Glucose tolerant subjects (n = 4935) | pAF | pGD | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Data are number of subjects with each genotype (% of each group) and percentage frequencies of the minor allele (MAF) (95% CI). The p values compare genotype distribution (pGD) and allele frequencies (pAF) between patients with type 2 diabetes and glucose tolerant subjects and were calculated using Fisher’s exact test (pAF) and logistic regression with adjustment for age, sex, and BMI (pGD) assuming a co-dominant model for the minor allele. | ||||||||||
| Ala203Pro | ||||||||||
| Ala/Ala | 1240 (87) | 1010 (86) | 4191 (85) | |||||||
| Ala/Pro | 186 (13) | 160 (14) | 717 (15) | |||||||
| Pro/Pro | 7 (0) | 7 (1) | 27 (1) | |||||||
| MAF | 7.0 (6.0 to 7.9) | 7.4 (6.3 to 8.4) | 7.8 (7.3 to 8.3) | 0.2 | 0.5 | |||||
| Arg265Gln | ||||||||||
| Arg/Arg | 1261 (91) | 1046 (91) | 4378 (90) | |||||||
| Arg/Gln | 125 (9) | 106 (9) | 462 (10) | |||||||
| Gln/Gln | 3 (0) | 2 (0) | 21 (0) | |||||||
| MAF | 4.7 (3.9 to 5.5) | 4.8 (3.9 to 5.6) | 5.2 (4.7 to 5.6) | 0.4 | 0.2 | |||||
| Arg292Ser | ||||||||||
| Arg/Arg | 1310 (93) | 1095 (94) | 4582 (94) | |||||||
| Arg/Ser | 92 (7) | 68 (6) | 276 (6) | |||||||
| Ser/Ser | 0 (0) | 2 (0) | 2 (0) | |||||||
| MAF | 3.3 (2.6 to 3.9) | 3.1 (2.4 to 3.8) | 2.9 (2.5 to 3.2) | 0.3 | 0.9 | |||||