Genotype distributions and allele frequencies of the PGC-1β variants in 7790 normal weight, overweight, and obese white Danish subjects
| Normal (n = 3129) | Overweight (n = 3085) | Obese (n = 1576) | pAF | pGD | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Normal: BMI <25.0 kg/m2; overweight: (BMI 25.0 to 29.9 kg/m2); obese: (BMI ⩾30.0 kg/m2).*Significant p values. Data are number of subjects with each genotype (% of each group) and percentage frequencies of the minor allele (MAF) (95% CI). The p values compare genotype distribution (pGD) and allele frequencies (pAF) between normal weight and obese subjects and were calculated using Fisher’s exact test (pAF) and logistic regression with adjustment for age and sex (pGD) assuming a co-dominant model for the minor allele. | ||||||||||
| Ala203Pro | ||||||||||
| Ala/Ala | 2636 (84) | 2631 (85) | 1380 (88) | |||||||
| Ala/Pro | 477 (15) | 436 (14) | 188 (12) | |||||||
| Pro/Pro | 16 (1) | 18 (1) | 8 (1) | |||||||
| MAF | 8.1 (7.5 to 8.8) | 7.6 (7.0 to 8.3) | 6.5 (5.6 to 7.3) | 0.004* | 0.009* | |||||
| Arg265Gln | ||||||||||
| Arg/Arg | 2767 (90) | 2743 (90) | 1391 (91) | |||||||
| Arg/Gln | 292 (10) | 280 (9) | 138 (9) | |||||||
| Gln/Gln | 8 (0) | 11 (0) | 8 (1) | |||||||
| MAF | 5.0 (4.5 to 5.6) | 5.0 (4.4 to 5.5) | 5.0 (4.2 to 5.8) | 1.0 | 0.3 | |||||
| Arg292Ser | ||||||||||
| Arg/Arg | 2890 (94) | 2864 (94) | 1458 (94) | |||||||
| Arg/Ser | 185 (6) | 176 (6) | 92 (6) | |||||||
| Ser/Ser | 0 (0) | 3 (0) | 1 (0) | |||||||
| MAF | 3.0 (2.6 to 3.4) | 3.0 (2.6 to 3.4) | 3.0 (2.4 to 3.6) | 0.9 | 0.5 | |||||