Univariate analysis of TNFα-857 SNP genotypes comparing the proportions of the −T group (CC) to the +T group (CT + TT) with risk factors for CD severity
| Phenotype | TNFα-857 genotype | Test statistic | p value | |||||
|---|---|---|---|---|---|---|---|---|
| CC (n = 232) | CT + TT (n = 43) | |||||||
| Group distribution for age at diagnosis and duration of disease shown for the two groups. Only risk factors with a p value of <0.2 are shown. These were further tested in multivariate analysis. | ||||||||
| Group distribution (years) | t | |||||||
| Mean (SD) age at diagnosis (years) | 28.7 (0.9) | 26.1 (1.9) | 1.45 | 0.23 | ||||
| Mean (SD) disease duration (years) | 11.6 (0.5) | 13.8 (1.0) | 3.54 | 0.06 | ||||
| Genotype distribution (n (%)) | ||||||||
| Multiplex family | χ2 | |||||||
| No | 167 (72.0) | 37 (86.1) | ||||||
| Yes | 65 (28.0) | 6 (13.9) | 3.75 | 0.05 | ||||
| Bowel resection | ||||||||
| No | 75 (32.3) | 19 (44.2) | ||||||
| Yes | 157 (67.7) | 24 (55.8) | 2.27 | 0.13 | ||||
| Site | ||||||||
| Ileal | 99 (43.4) | 12 (27.9) | ||||||
| Ileocolonic | 82 (36.0) | 23 (53.5) | ||||||
| Colonic | 47 (20.6) | 8 (18.6) | 5.07 | 0.08 | ||||
| Phenotype | ||||||||
| Stricturing | 70 (30.8) | 9 (21.4) | ||||||
| Penetrating | 87 (38.3) | 12 (28.6) | ||||||
| Non-stricturing | 70 (30.9) | 21 (50.0) | 5.83 | 0.05 | ||||
| Granuloma | ||||||||
| No | 101 (46.1) | 14 (34.2) | ||||||
| Yes | 118 (53.9) | 27 (65.8) | 2.01 | 0.16 | ||||
| Stricturing | ||||||||
| Never | 117 (51.5) | 28 (66.7) | ||||||
| Ever | 110 (48.5) | 14 (33.3) | 3.26 | 0.07 | ||||