Comparison of sex ratio data
| Total families | Mutation | Male | Female | p Value* | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| *Compared with BRCA1 mutation carriers. | ||||||||||
| UPenn, University of Pennsylvania (current study). | ||||||||||
| de la Hoya et al5 | 17 | BRCA1 | 65 (33%) | 133 (67%) | ||||||
| 15 | BRCA2 | 85 (47%) | 97 (53%) | 0.006 | ||||||
| 36 | Tested negative | 315 (48%) | 344 (52%) | <0.001 | ||||||
| UPenn | 180 | BRCA1 | 337 (42%) | 458 (58%) | ||||||
| 99 | BRCA2 | 123 (46%) | 145 (54%) | 0.32 | ||||||
| 389 | Tested negative | 237 (42.6%) | 319 (57.4%) | 0.93 | ||||||
| 608 | Untested | 597 (40.9%) | 862 (59.1%) | 0.50 | ||||||