Expression of STRA13 and CA IX in benign and malignant human tumours
| Tumour category | Cases studied (n) | STRA13: | CA IX: | |||||
|---|---|---|---|---|---|---|---|---|
| Positive cytoplasmic (C+) and/or nuclear (N+) staining (n (%)) | Positive staining (n (%)) | |||||||
| (C+) and (N+) | C+ only | N+ only | High N+ expression (>25%) | Membrane/cytoplasm | ||||
| Adenoca, adenocarcinoma; Ca, carcinoma; CIN, cervical intraepithelial neoplasia; LMP, low malignancy potential; PNET, primitive neurectodermal tumour. | ||||||||
| Cervix | ||||||||
| Carcinomas | 28 | 23 (82) | 2 (7) | 21 (75) | 10 (36) | 27 (96) | ||
| Squamous cell Ca | 15 | 15 (100) | 2 (7) | 13 (87) | 6 (40) | 14 (92) | ||
| Adenoca | 9 | 7 (78) | 0 | 7 (78) | 4 (44) | 9 (100) | ||
| Adenosquamous Ca | 4 | 1 (33) | 0 | 1 (33) | 0 | 4 (100) | ||
| CIN (I–III) | 14 | 13 (93) | 6 (40) | 7 (50) | 7 (50) | 14 (100) | ||
| In situ adenoca | 4 | 4(100) | 0 | 4 (100) | 3 (75) | 4 (100) | ||
| Uterine corpus | ||||||||
| Endometrial Ca | 9 | 9 (100) | 2 (22) | 9 (100) | 4 (44) | 9 (100) | ||
| Ovary | ||||||||
| Epithelial Ca of all types | 25 | 18 (72) | 0 | 18 (72) | 9 (36) | 20 (80) | ||
| Cystadenoma benign or LMP | 13 | 13 (100) | 1 (8) | 12 (92) | 12 (92) | 13 (100) | ||
| Sex cord tumour | 6 | 4 (67) | 4 (67) | 0 | 0 | 3 (50) | ||
| Metastatic Ca of colon primary | 4 | 4 (100) | 4 (100) | 0 | 0 | 4 (100) | ||
| Germ cell tumour | 5 | 3 (60) | 0 | 3 (60) | 0 | 2 (40) | ||
| Breast | ||||||||
| Ductal Ca | 40 | 26 (70) | 8 (25) | 22 (55) | 12 (30) | 14 (35) | ||
| high grade | 15 | 9 (60) | 8 (53) | 3 (20) | 1 (6) | 11 (73) | ||
| intermediate/low grade | 25 | 19 (76) | 2 (8) | 19 (76) | 11 (44) | 3 (12) | ||
| Lobular Ca | 11 | 11 (100) | 1 (9) | 11(100) | 11 (100) | 0 | ||
| Kidney/urinary tract | ||||||||
| Transitional cell Ca | 11 | 10 (91) | 0 | 10 (91) | 8 (73) | 11 (100) | ||
| Squamous cell Ca | 3 | 3 (100) | 3 (100) | 0 | 0 | 3 (100) | ||
| Renal cell Ca | 42 | 36 (86) | 22 (52) | 19 (45) | 15 (36) | 34 (81) | ||
| Subtype: | ||||||||
| Clear cell | 25 | 19 (76) | 5 (20) | 19 (76) | 14(56) | 25 (100) | ||
| Papillary | 6 | 6 (100) | 6 (100) | 0 | 0 | 6 (100) | ||
| Chromophobe cell | 8 | 8 (0) | 8 (0) | 0 | 0 | 0 | ||
| Collecting duct | 3 | 3 (100) | 3 (100) | 0 | 0 | 3 (100) | ||
| Oncocytoma | 7 | 7 (100) | 7 (100) | 0 | 0 | 0 | ||
| Tubular adenoma | 2 | 2 (100) | 2 (100) | 0 | 0 | 0 | ||
| Wilm’s tumour | 3 | 3 (100) | 1 (33) | 2 (67) | 0 | 2 (67) | ||
| Prostate | ||||||||
| Adenocarcinoma | 2 | 0 | 0 | 0 | 0 | 0 | ||
| Gastrointestinal tract | ||||||||
| Stomach/duodenum adenoca | 3 | 3 (100) | 3 (100) | 1 (33) | 1 (33) | 3 (100) | ||
| Colon/pancreas adenoca | 40 | 34 (85) | 32 (80) | 13 (33) | 0 | 37 (93) | ||
| Colon adenoma | 3 | 3 (100) | 3 (100) | 0 | 0 | 3 (100) | ||
| Liver | ||||||||
| Hepatoma | 6 | 5 (83) | 5 (83) | 0 | 0 | 3 (50) | ||
| Bile duct adenoma | 2 | 2 (100) | 2 (100) | 2 (100) | 2 (100) | 2 (100) | ||
| Lung | ||||||||
| Squamous cell Ca | 12 | 12 (100) | 12 (100) | 9 (75) | 9 (75) | 12 (100) | ||
| AdenoCa | 13 | 12 (92) | 4 (31) | 11 (85) | 8 (73) | 10 (77) | ||
| Head and Neck | ||||||||
| Squamous cell Ca | 10 | 10 (100) | 8 (80) | 6 (60) | 4 (67) | 10 (100) | ||
| Inverted papilloma | 2 | 2 (100) | 0 | 2 (100) | 2 (100) | 2 (100) | ||
| Salivary glands | ||||||||
| Pleomorphic adenoma | 4 | 4 (100) | 4 (100) | 0 | 0 | 2 (50) | ||
| Mucoepidermoid Ca | 3 | 3 (100) | 3 (100) | 0 | 0 | 3 (100) | ||
| Acinic cell Ca | 4 | 3 (75) | 0 | 3 (75) | 3 (75) | 0 | ||
| Thyroid gland | ||||||||
| Papillary/follicular Ca | 3 | 3 (100) | 3 (100) | 0 | 0 | 0 | ||
| Tumours with secretory gramules | ||||||||
| PNET | 2 | 1 (50) | 0 | 1 (50) | 1 (100) | 0 | ||
| Neuroblastoma | 10 | 7 (70) | 7 (70) | 0 | 0 | 0 | ||
| Paraganglioma | 2 | 2 (100) | 2 (100) | 0 | 0 | 0 | ||
| Phaeochromocytoma | 2 | 0 | 0 | 0 | 0 | 0 | ||
| Neuroendocrine Ca | 4 | 1 (25) | 0 | 1(25) | 1 (100) | 4 (100) | ||
| Carcinoid tumour | 5 | 4 (80) | 2 (40) | 5 (80) | 2 (40) | 0 | ||
| Central nervous system | ||||||||
| Glioma | ||||||||
| Low grade (grade I–II) | 7 | 7 (71) | 1 (14) | 7 (71) | 1 (14) | 0 | ||
| High grade/glioblastoma | 8 | 7 (88) | 7 (100) | 7 (88) | 7 (88) | 8 (100) | ||
| Oligodendroglioma | 2 | 0 | 0 | 0 | 0 | 0 | ||
| Ependymoma | 4 | 0 | 0 | 0 | 0 | 4 (100) | ||
| Meningioma | 2 | 2 (100) | 2 (100) | 0 | 0 | 2 (100) | ||
| Choroid plexus tumour | 3 | 3 (100) | 3 (100) | 2(67) | 1(33) | 3 (100) | ||
| Body cavity | ||||||||
| Mesothelioma | 2 | 1 (50) | 0 | 1 (50) | 1 (100) | 2 (100) | ||
| Skin | ||||||||
| Squamous/basal cell Ca | 5 | 5 (100) | 5 (100) | 0 | 0 | 4 (80) | ||
| Melanoma | 2 | 0 | 0 | 0 | 0 | 0 | ||