Proteins that can associate with fibrillin-rich microfibrils but do not serve an integral structural function in them
| Protein | Class of protein | Potential biological role of interaction |
|---|---|---|
| Elastin | – | Tropoelastin deposition78 |
| Regulation of microfibril formation75 | ||
| LTBP-1 | Fibrillin-LTBP | Sequestering of latent TGFβ102 |
| LTBP-2 | Fibrillin-LTBP | Structural role?103 |
| LTBP-4 | Fibrillin-LTBP | Sequestering of latent TGFβ102 |
| Versican | Proteoglycan (hyalectin) | Link fibrillin-microfibrils to versican/hyaluronan network104 |
| Perlecan | Proteoglycan (hyalectin) | Anchoring microfibrils to basement membranes and in the |
| biogenesis of microfibrils69 | ||
| Heparin/heparan sulfate | Proteoglycan | Binding of related heparan sulfate chains may regulate cell-surface |
| assembly of fibrillin66 | ||
| Decorin | Small dermatan sulfate proteoglycan | Induction of fibrillin-1 expression in renal fibroblasts and mesangial cells105 |
| Biglycan | Small dermatan sulfate proteoglycan | Role in elastogenesis77 |
| Fibulin-2 | Fibulin | Mediate/modulate attachment of fibrillin to tropoelastin106 |
| Fibulin-5 | Fibulin | Regulation of the initial deposition of tropoelastin on to microfibrils107 |
| BMP-7 | Bone morphogenetic protein | Regulation of limb patterning12 |
| EMILIN-1 | Elastin-microfibril interface located proteins | Role in elastinogenesis108 |