Mean (SD) lung function of individuals with severe and intermediate AATD
| Genotype | FEV1† | FEV1/FVC | |
|---|---|---|---|
| Three PI*ZZ, four PI*SZ, one PI*MZ, and one M/R subjects were excluded because of insufficient data. | |||
| *p = 0.00095 v PI*SZ ; **p = 0.009 v PI*SZ; ***p = 0.0034 v PI*MZ. | |||
| †Pre-bronchodilator, % predicted. | |||
| PI*ZZ | Total, n = 93 | 57 (32) | 0.57 (0.31) |
| COPD, n = 73 | 45 (21) | 0.51 (0.31) | |
| PI*SZ | Total, n = 17 | 82 (36) | 0.71 (0.22) |
| COPD, n = 7 | 48 (29) | 0.49 (0.20) | |
| R/D | Total, n = 15(all COPD) | 39 (18)* | 0.39 (0.12)** |
| PI*MZ | Total, n = 70 | 94 (29) | 0.74 (0.15) |
| COPD, n = 27 | 69 (24) | 0.61 (0.14) | |
| M/R | Total, n = 12 | 78 (35) | 0.67 (0.23) |
| COPD, n = 5 | 40 (11)*** | 0.45 (0.21) | |