VEGF genotype frequencies in patients with one, two, and three vessel disease
| SNP | Geno type | The sample as a whole | After excluding patients with MI | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| One vessel disease | Two vessel disease | Three vessel disease | OR (95% CI) | *OR (95% CI) | One vessel disease | Two vessel disease | Three vessel disease | OR (95% CI) | *OR (95% CI) | ||
| *Adjusted for age, sex, body mass index, smoking, hypercholesterolaemia, lipid lowering treatment, hypertension, and diabetes. Ref., reference. | |||||||||||
| −2578 | AA | 107 (27.2%) | 90 (27.7%) | 76 (34.1%) | 1.28 (0.92 to 1.79) p = 0.149 | 1.29 (0.91 to 1.82) p = 0.149 | 54 (25.8%) | 42 (32.8%) | 36 (38.3%) | 2.27 (1.38 to 3.74) p = 0.001 | 2.25 (1.35 to 3.77) p = 0.002 |
| AC | 194 (49.4%) | 168 (51.7%) | 100 (44.8%) | 1.05 (0.77 to 1.42) p = 0.755 | 1.07 (0.78 to 1.46) p = 0.695 | 92 (44.0%) | 61 (47.7%) | 43 (45.7%) | 1.75 (1.11 to 2.79) p = 0.019 | 1.73 (1.07 to 2.82) p = 0.026 | |
| CC | 92 (23.4%) | 67 (20.6%) | 47 (21.1%) | Ref. | Ref. | 63 (30.1%) | 25 (19.5%) | 15 (16.0%) | Ref. | Ref. | |
| Total | 393 (100%) | 325 (100%) | 223 (100%) | 209 (100%) | 128 (100%) | 94 (100%) | |||||
| χ2 test | p = 0.331 | p = 0.030 | |||||||||
| −1154 | GG | 184 (45.9%) | 131 (40.4%) | 94 (41.2%) | 0.82 (0.56 to 1.20) p = 0.302 | 0.87 (0.60 to 1.31) p = 0.544 | 107 (50.5%) | 53 (40.8%) | 33 (34.4%) | 0.55 (0.32 to 0.94) p = 0.029 | 0.65 (0.37 to 1.12) p = 0.121 |
| AG | 165 (41.1%) | 164 (50.6%) | 97 (42.5%) | 0.96 (0.66 to 1.40) p = 0.832 | 1.02 (0.69 to 1.50) p = 0.926 | 77 (36.3%) | 62 (47.7%) | 43 (44.8%) | 0.90 (0.53 to 1.52) p = 0.686 | 0.99 (0.57 to 1.71) p = 0.975 | |
| AA | 52 (13.0%) | 29 (9.0%) | 37 (16.2%) | Ref. | Ref. | 28 (13.2%) | 15 (11.5%) | 20 (20.8%) | Ref. | Ref. | |
| Total | 401 (100%) | 324 (100%) | 228 (100%) | 212 (100%) | 130 (100%) | 96 (100%) | |||||
| χ2 test | p = 0.024 | p = 0.028 | |||||||||
| −634 | GG | 169 (44.0%) | 144 (44.2%) | 100 (46.3%) | 1.14 (0.77 to 1.69) p = 0.516 | 1.24 (0.83 to 1.86) p = 0.303 | 82 (41.0%) | 60 (45.8%) | 44 (48.9%) | 1.09 (0.61 to 1.92) p = 0.776 | 1.18 (0.65 to 2.13) p = 0.580 |
| CG | 165 (43.0%) | 151 (46.3%) | 89 (41.2%) | 1.09 (0.74 to 1.63) p = 0.654 | 1.14 (0.76 to 1.72) p = 0.515 | 92 (46.0%) | 58 (44.3%) | 32 (35.6%) | 0.81 (0.46 to 1.44) p = 0.480 | 0.89 (0.49 to 1.60) p = 0.687 | |
| CC | 50 (13.0%) | 31 (9.5%) | 27 (12.5%) | Ref. | Ref. | 26 (13.0%) | 13 (9.9%) | 14 (15.6%) | Ref. | Ref. | |
| Total | 384 (100%) | 326 (100.0%) | 216 (100%) | 200 (100%) | 131 (100.0%) | 90 (100%) | |||||
| χ2 test | p = 0.544 | p = 0.406 | |||||||||