Risk of lung cancer related to FAS and FASL genotypes by age and smoking status
| FAS −1377 genotype | OR† (95% CI) | p value‡ | FASL −844 genotype | OR† (95% CI) | p value‡ | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AA* | GG+GA* | CC* | TT+TC* | |||||||||||||
| *Number of patients/number of controls. †Data were calculated by unconditional logistic regression with the FAS −1377GG+GA or FASL −844TT+TC genotype as reference group and adjusted for sex, age, smoking status, and pack years with the strata. OR, odds ratio; CI, confidence interval. ‡Two sided χ2 test. ¶Includes 90 undifferentiated cancers, 90 bronchioalveolar carcinomas, 24 small cell carcinomas (SCC), and 51 mixed cell carcinomas. | ||||||||||||||||
| Smoking status | ||||||||||||||||
| Nonsmoker | 52/80 | 298/545 | 1.23 (0.83 to 1.81) | 0.306 | 224/303 | 126/322 | 1.84 (1.40 to 2.43) | <0.001 | ||||||||
| Smoker | 102/50 | 548/595 | 2.12 (1.46 to 3.07) | <0.001 | 388/298 | 262/347 | 1.70 (1.35 to 2.14) | <0.001 | ||||||||
| Pack years smoked | ||||||||||||||||
| ⩽20 | 27/16 | 163/289 | 2.92 (1.51 to 5.66) | 0.001 | 106/150 | 84/155 | 1.37 (0.94 to 1.98) | 0.099 | ||||||||
| >20 | 75/34 | 385/306 | 1.84 (1.18 to 2.89) | 0.008 | 282/148 | 178/192 | 1.96 (1.45 to 2.64) | <0.001 | ||||||||
| Histological type | ||||||||||||||||
| SCC | 68/130 | 380/1140 | 1.73 (1.22 to 2.44) | 0.002 | 274/601 | 174/669 | 1.78 (1.40 to 2.26) | <0.001 | ||||||||
| Adenocarcinoma | 47/130 | 250/1140 | 1.63 (1.13 to 2.35) | 0.010 | 176/601 | 121/669 | 1.67 (1.29 to 2.17) | <0.001 | ||||||||
| Other¶ | 39/130 | 216/1140 | 1.66 (1.12 to 2.47) | 0.012 | 162/601 | 93/669 | 1.96 (1.48 to 2.61) | <0.001 | ||||||||