Marker | Associated allele† | θ | Pn | Pd | δ | ĝ | Labuda corrections* | |||
---|---|---|---|---|---|---|---|---|---|---|
r = 1.60 | r = 1.50 | |||||||||
Risch et al5 estimated mutation age using generations ĝ = 1n(δ)/1n(1−θ), where θ is the recombination fraction between the marker and the mutation, Pn and Pd are the frequencies of the associated marker allele on normal and mutation carrying chromosomes, respectively, and linkage disequilibrium between the marker and the mutation is measured by δ = (Pd−Pn)/(1−Pn). Twenty five years per generation was assumed, and r denotes the growth rate per generation. | ||||||||||
*Labuda corrections are added to the single locus estimates (ĝ) to obtain unbiased estimates of mutation age under the assumptions of a bifurcating genealogy. | ||||||||||
†See Foulkes et al3 for details of allele numbering. | ||||||||||
D2S2331 | 4 | 0.077 | 0.22 | 0.49 | 0.35 | 13.25 | 3.36 | 3.61 | ||
D2S2306 | 4 | 0.045 | 0.35 | 0.82 | 0.72 | 7.18 | 4.50 | 4.93 | ||
Rs868542 | C | 0.021 | 0.70 | 0.68 | −0.07 | NA | ||||
D2S391 | 2 | 0.011 | 0.19 | 0.69 | 0.61 | 42.40 | 7.42 | 8.31 | ||
Rs1374749 | A | 0.0098 | 0.52 | 0.77 | 0.51 | 67.33 | 7.75 | 8.69 | ||
Rs896213 | G | 0.0040 | 0.38 | 0.89 | 0.81 | 51.11 | 9.65 | 10.89 | ||
D2S2227 | 3 | 0.00039 | 0.28 | 0.82 | 0.76 | 723.03 | 14.63 | 16.67 | ||
MSH2*1906G→C | – | 0.0 | 0.0 | 1.0 | NA | NA | ||||
CA3 | 139 | 0.00088 | 0.15 | 0.83 | 0.80 | 256.79 | 12.89 | 14.65 | ||
CA1 | 143 | 0.00090 | 0.13 | 0.82 | 0.79 | 256.33 | 12.84 | 14.59 | ||
CA2 | 250 | 0.0011 | 0.54 | 0.94 | 0.86 | 136.55 | 12.41 | 14.10 | ||
D2S123 | 6 | 0.049 | 0.48 | 0.60 | 0.23 | 29.11 | 4.32 | 4.71 |