Estimated age in years of the Ala12 allele of the PPARG gene using both linkage disequilibrium and allele frequency
| Population* | MLE (95% CI) using linkage disequilibrium | MLE (95% CI) using frequency of the Ala12 allele | ||||
|---|---|---|---|---|---|---|
| θ = 0.0016 | θ = 0.0008 | θ = 0.0004 | r = 0.01 | r = 0.02 | r = 0.04 | |
| MLE, maximum likelihood estimator. *D′, standardised LD coefficient between Pro12Ala and C1431T SNPs; n, sample size; N0, current population size. | ||||||
| Scottish,7 | 6845 | 13 690 | 27 375 | 23 900 | 12 825 | 6850 |
| N0∼5×106, | (5500–8405) | (11 000–16 815) | (22 000–33 625) | (22 400–30 125) | (12 050–15 950) | (6475–8400) |
| D′ = 0.608, | ||||||
| n = 973 | ||||||
| Chinese,6 | 8960 | 17 920 | 35 845 | 33 775 | 17 750 | 9325 |
| N0∼1×109, | (6795–11 665) | (13 595–23 330) | (27 190–46 655) | (32 175–42 475) | (16 950–22 100) | (8900–11 475) |
| D′ = 0.555, | ||||||
| n = 2730 | ||||||
| Malays,6 | 8565 | 17 125 | 34 250 | 24 000 | 12 850 | 6875 |
| N0∼23×106, | (4795–14 415) | (9595–28 830) | (19 190–57 655) | (22 050–32 875) | (11 900–17 300) | (6375–9100) |
| D′ = 0.572, | ||||||
| n = 740 | ||||||
| Indians,6 | 3195 | 6390 | 12 780 | 36 700 | 19 225 | 10 050 |
| N0∼1×109, | (2030–4740) | (4065–9485) | (8125–18 970) | (35 100–43 300) | (18 425–22 525) | (9650–11 700) |
| D′ = 0.799, | ||||||
| n = 568 | ||||||