Table 4

Allele frequency in patients with and without known mutations in CFH, MCP and IF

	Control allele frequency		HUS – mutation negative allele frequency			HUS – mutation positive allele frequency
	1	2	1	2	p Value	1	2	p Value
CFH, complement factor H; HUS, haemolytic-uraemic syndrome; MCP, membrane cofactor protein.
Newcastle cohort (n = 22 mutation positive)
CFH −257C→T	71	29	52	48	0.001	64	36	0.38
CFH c.2089A→G	87	13	64	36	<0.001	71	29	0.019
CFH c.2881G→T	81	19	65	35	0.002	76	24	0.52
MCP c.IVS12+638G→A	62	38	43	57	0.001	45	55	0.038
MCP c.2232T→C	58	42	43	57	0.018	45	55	0.14

Paris cohort (n = 39 mutation positive)
CFH −257C→T	80	20	59	41	0.012	51	49	<0.001
CFH c.2089A→G	84	16	76	24	0.182	64	36	0.001
CFH c.2881G→T	84	16	76	24	0.143	57	43	<0.001
MCP −547A→G	62	38	42	58	0.005	39	61	0.001
MCP-261A→G	63	37	42	58	0.005	39	61	<0.001
MCP c.IVS8+23T→G	80	20	55	45	<0.001	53	47	<0.001
MCP c.IVS9-78G→A	66	34	43	57	0.001	43	57	0.001
MCP c.2232T→C	64	36	45	55	0.006	41	59	0.001