Potential function domains found in candidates with amino acid alterations caused by single nucleotide polymorphisms: four kinds of diseases
| Category | QTL | Chr | SNP ID | Gene name | Domain description |
|---|---|---|---|---|---|
| QTL = quantitative trait loci found in different category; Chr = mouse chromosome; SNP ID = specific identification number for the SNP from Celera discovery system; Gene name = name as in Celera’s annotation; Domain description = description as in NCBI Conserved Domain Database. | |||||
| Ali1/Ali2/Ali 3, acute lung injury quantitative trait loci; Bis1, -carboline induced seizure quantitative trait locus; Exq1, exploratory and excitability quantitative trait locus; MLT1/MLT2/MLT3, mouse lung tumour quantitative trait loci. | |||||
| Lung tumour | MLT1 | 4 | mCV23761092 | Cdh17 | KOG4289, cadherin EGF LAG seven-pass G-type receptor |
| mCV23250954 | Gpr63 | KOG4220, muscarinic acetylcholine receptor | |||
| MLT2 | 6 | mCV23322871 | LOC272322 | KOG3561, aryl-hydrocarbon receptor nuclear translocator | |
| mCV23327408 | Mrps35 | KOG3933, mitochondrial ribosomal protein S28 | |||
| MLT3 | 8 | mCV22993688 | ADAM29 | KOG3607, meltrins, fertilins, and related Zn dependent metalloproteinases of the ADAMs family | |
| Acute lung injury | Ali1 | 11 | mCV24258169 | Rad51l3 | KOG1433, DNA repair protein RAD51/RHP55 |
| mCV22737741 | Mpo | KOG2408, peroxidase/oxygenase | |||
| mCV24690994 | Akap | KOG2279, kinase anchor protein AKAP149, contains KH and Tudor RNA binding domains | |||
| mCV23174311 | Map3k14 | KOG0198, MEKK and related serine/threonine protein kinases | |||
| Ali2 | 13 | mCV23280804 | Fgfr4 | KOG0200, fibroblast/platelet derived growth factor receptor and related receptor tyrosine kinases | |
| mCV22736530 | Gprk6 | KOG0986, G protein coupled receptor kinase | |||
| Ali3 | 17 | mCV22724951 | Xdh | Xanthine dehydrogenase, iron-sulphur cluster and FAD-binding subunit A | |
| Trypanosomiasis | Tir1 | 17 | mCV24105832 | Daxx | Daxx family |
| mCV24297661 | Notch4 | KOG4289, cadherin EGF LAG seven-pass G-type receptor | |||
| Tir3 | 1 | mCV24438398 | Ddr2 | KOG1094, discoidin domain receptor DDR1 | |
| mCV24426932 | Fcgr2b | Immunoglobulin | |||
| mCV24401565 | Cd84 | T cell surface antigen CD2 protein | |||
| Seizure | Exq1 | 10 | mCV23280479 | Lta4h | KOG1047, bifunctional leukotriene A4 hydrolase/aminopeptidase LTA4H |
| mCV25027371 | Iltif | Interleukin 10 | |||
| Bis1 | 4 | mCV24214187 | Cnr2 | 7 Transmembrane receptor (rhodopsin family). | |
| mCV25390842 | C1qb | Complement component C1q domain. | |||
| mCV25359925 | Hspg2 | KOG3513, neural cell adhesion molecule L1 | |||
| mCV24058160 | Kif17 | KOG0242, kinesin-like protein | |||