Summary of confirmed SNPs with the confirmed amino acid alterations: seizure locus
| Chr | QTL | SNP ID | GenBank | Gene name | SNP type | Chr positive | Conf amino acid | Description |
|---|---|---|---|---|---|---|---|---|
| Chr = mouse chromosome; QTL = quantitative trait loci, seizure locus regions; SNP ID = specific identification number for the SNP from Celera discovery system; GenBank = transcript sequence associated with the gene containing the SNP; Gene name = derived from Celera’s annotation; Chr position = the base pair position of the SNP on the chromosome according to the Celera database; Conf amino acid = confirmed amino acid alteration with the order of A/J mice/C57BL/6J mice; Description = description derived from either Celara annotation or GenBank annotation. | ||||||||
| Bis1/Bis 4, -carboline induced seizure quantitative trait loci; Exq1, exploratory and excitability quantitative trait locus; SNP, single nucleotide polymorphism. | ||||||||
| 10 | Exq1 | mCV23280479 | M63848 | Lta4h | Mis-sense | 92458232 | GCC(447)ACC | Leukotriene A4 hydrolase |
| mCV22619310 | NM_011629 | Nr2c1 | Mis-sense | 93147494 | TTC(327)GCC | Nuclear receptor subfamily 2, group C, member 1 | ||
| mCV25154635 | AK014477 | 4432405K22Rik | Mis-sense | 114131473 | GTA(586)ATA | RIKEN cDNA 4432405K22 gene, similar to hypothetical protein | ||
| mCV25027371 | AJ249491 | Iltif | Mis-sense | 117159257 | AAT(84)AGT | Interleukin 10 related, T cell derived inducible factor | ||
| 4 | Bis1 | mCV24806112 | BC019461 | 4930506L07Rik | Mis-sense | 129294444 | CAG(100)CGG | RIKEN cDNA 4930506L07 gene |
| mCV22573664 | NM_019578 | Extl1 | Mis-sense | 129550916 | ATA(190)TTA | Exostoses (multiple)-like 1 | ||
| mCV22573663 | Mis-sense | 129551389 | TCG(32)TTG | |||||
| mCV22570075 | NM_016799 | Srrm1 | Mis-sense | 130522801 | CCG(814)CTG | Serine/arginine repetitive matrix 1 | ||
| mCV22566918 | BC006598 | 0610011E17Rik | Mis-sense | 131066845 | CTT(41)CAT | RIKEN cDNA 0610011E17 gene | ||
| mCV24214187 | NM_009924 | Cnr2 | Mis-sense | 131118228 | ATG(272)ACG | Cannabinoid receptor 2 (macrophage) | ||
| mCV22559909 | NM_008309 | Htr1d | Mis-sense | 131636502 | GTG(22)GCG | 5-Hydroxytryptamine (serotonin) receptor 1D | ||
| mCV25390842 | NM_009777 | C1qb | Mis-sense | 132088168 | AGG(115)GGG | Complement component 1, q subcomponent, beta polypeptide | ||
| mCV25359925 | NM_008305 | Hspg2 | Mis-sense | 132762092 | CTG(2670)GTG | Perlecan (heparan sulphate proteoglycan 2) | ||
| mCV24058160 | NM_010623 | Kif17 | Mis-sense | 137068356 | GTG(508)ATG | Kinesin 17 | ||
| mCV22902154 | NM_019763 | Mint-pending | Mis-sense | 140291439 | CCG(2317)CAG | Msx2 interacting nuclear target protein | ||
| mCV22902161 | Mis-sense | 140291628 | GCG(2254)GTG | |||||
| mCV22902179 | Mis-sense | 140295089 | CAG(1098)CAC | |||||
| mCV22902180 | Mis-sense | 140295255 | GCG(1043)GTG | |||||
| mCV22902197 | Mis-sense | 140295958 | GCC(809)ACC | |||||
| 7 | Bis4 | mCV22777117 | NM_007633 | Ccne1 | Mis-sense | 30257794 | CAG(179)CAT | Cyclin E1 |
| mCV22884690 | NM_013624 | Otog | Mis-sense | 38762493 | CAG(2020)AAG | Otogelin | ||