Summary of confirmed single nucleotide polymorphisms with the confirmed amino acid alterations: trypanosomiasis resistance
| Chr | QTL | SNP ID | GenBank | Gene name | SNP type | Chr position | Conf amino acid | Description |
|---|---|---|---|---|---|---|---|---|
| Chr = mouse chromosome; QTL = quantitative trait loci, trypanosomiasis resistance locus regions; SNP ID = specific identification number for the SNP from Celera discovery system; GenBank = transcript sequence associated with the gene containing the SNP; Gene name = derived from Celera’s annotation; Chr position = the base pair position of the SNP on the chromosome according to the Celera database; Conf amino acid = confirmed amino acid alteration with the order of A/J mice/C57BL/6J mice; Description = derived from either Celara annotation or GenBank annotation. | ||||||||
| Tir1/Tir2/Tir3, trypanosomiasis resistance quantitative trait loci; SNP, single nucleotide polymorphism. | ||||||||
| 17 | Tir1 | mCV24105117 | D49544 | Kifc1 | Mis-sense | 33637767 | GGA(124)GGT | Kinesin family member C1 |
| mCV24105832 | AF006040 | Daxx | Mis-sense | 33664471 | AGC(179)AAC | Fas binding protein | ||
| mCV24106508 | BC015074 | Tapbp | Mis-sense | 33679020 | TCG(328)GCG | TAP binding protein | ||
| mCV23315924 | BC013802 | Abcb2 | Mis-sense | 33943094 | CAT(88)CGT | ATP binding cassette, subfamily B (MDR/TAP), member 2 | ||
| mCV23315948 | Mis-sense | 33944221 | GAC(130)GGC | |||||
| mCV23317283 | BC013785 | Psmb8 | Mis-sense | 33954831 | CGA(272)GGA | Proteosome (prosome, macropain) subunit, β type 8 (large multifunctional protease 7) | ||
| mCV23318016 | BC005578 | Abcb3 | Mis-sense | 33966976 | AGG(449)AAG | ATP binding cassette, sub-family B (MDR/TAP), member 3 | ||
| mCV23950081 | U28489 | H2-Eb1 | Mis-sense | 34071900 | CCG(119)CGG | Histocompatibility 2, class II antigen E β | ||
| mCV24297661 | U43691 | Notch4 | Mis-sense | 34678075 | CCA(1245)CTA | Notch gene homolog 4 (Drosophila) | ||
| mCV24297624 | Mis-sense | 34679577 | CCT(1437)TCT | |||||
| mCV24296571 | NM_019873 | Fkbpl | Mis-sense | 34740447 | ACC(6)ATC | FK506 binding protein-like | ||
| mCV24295566 | NM_031176 | Tnxb | Mis-sense | 34777277 | CGT(965)AGT | Tenascin XB | ||
| mCV22968016 | Mis-sense | 34792079 | CCC(2056)TCC | |||||
| mCV22968004 | Mis-sense | 34799613 | TCT(2386)CCT | |||||
| mCV22965186 | NM_020027 | Bat2 | Mis-sense | 35255946 | ATT(564)GTT | HLA-B associated transcript 2 | ||
| mCV22964932 | U16985 | Ltb | Mis-sense | 35291886 | TTC(97)TCC | Lymphotoxin-β | ||
| mCV22964931 | Mis-sense | 35291888 | TAT(98)AAT | |||||
| mCV24434154 | AB046382 | Rnf23 | Mis-sense | 36741549 | GCC(11)ACC | Ring finger protein 23 | ||
| mCV23240622 | AF220121 | Trim10 | Mis-sense | 37296242 | GTG(368)ATG | Tripartite motif protein 10 | ||
| mCV22570535 | BC026834 | Guca1a | Mis-sense | 47835206 | GTC(4)ATC | Guanylate cyclase activator 1a (retina) | ||
| mCV23317880 | BC006018 | Mdfi | Mis-sense | 48261627 | GGG(67)CGG | MyoD family inhibitor | ||
| 5 | Tir2 | mCV24595131 | NM_010727 | Lnx1 | Silent | 68872796 | GAA(417)GAG | Ligand of numb-protein X 1 |
| mCV23061782 | Silent | 68885173 | CTT(255)CTG | |||||
| mCV23860455 | M30643 | Fgf5 | Silent | 92599216 | CGA(203)CGG | Fibroblast growth factor 5 | ||
| 1 | Tir3 | mCV24438398 | NM_022563 | Ddr2 | Mis-sense | 169428973 | GGC(555)GAC | Discoidin domain receptor family, member 2 |
| mCV24426932 | NM_010187 | Fcgr2b | Mis-sense | 170416198 | CAG(200)CTG | Fc receptor, IgG, low affinity IIb | ||
| mCV24422422 | AK002459 | 0610010E03Ri | Mis-sense | 170598815 | CTC(4)TTC | RIKEN cDNA 0610010E03 gene | ||
| mCV24411266 | NM_008534 | Ly9 | Mis-sense | 171451576 | GAG(571)GGG | Lymphocyte antigen 9 | ||
| mCV24401565 | NM_013489 | Cd84 | Mis-sense | 171707823 | ATG(27)GTG | CD84 antigen | ||
| mCV24580691 | NM_010184 | Fcer1a | Mis-sense | 173074477 | GAA(182)AAA | Fc receptor, IgE, high affinity I, α polypeptide | ||
| mCV23713265 | NM_023173 | Dusp12 | Mis-sense | 176989475 | ACG(42)GTG | Dual specificity phosphatase 12 | ||
| mCV24023687 | NM_010094 | Ebaf | Mis-sense | 184999571 | TCA(2)CCA | Endometrial bleeding associated factor | ||