Frequency of KRT8 mutations (G62C and Y54H) in patients with chronic liver diseases of different aetiologies and healthy controls
| Groups | Number of individuals studied | G62C | Y54H |
|---|---|---|---|
| *The group of patients with miscellaneous liver disorders included 21 patients with hepatocellular carcinoma, six patients with cholangiocellular carcinoma, two patients with liver metastases of neuroendocrine tumours, 32 patients with acute liver failure, 14 patients with Budd Chiari’s syndrome, one patient with pregnancy induced cholestasis, 54 patients with metabolic/genetic liver disorders, nine patients with drug-induced liver disease, six patients with biliary cirrhosis, two patients with extrahepatic biliary atresia, and one patient with sarcoidosis. HBV, hepatitis B virus; HCV, hepatitis C virus. | |||
| All patients | 1668 | 27 (1.6%) | 2 (0.1%) |
| Chronic HCV infection | 672 | 13 (1.9%) | 1 (0.1%) |
| Alcoholic liver disease | 215 | 4 (1.9%) | – |
| Chronic HBV infection | 200 | 1 (0.5%) | 1 (0.5%) |
| Primary biliary cirrhosis | 162 | 1 (0.6%) | – |
| Autoimmune hepatitis | 104 | 4 (3.8%) | – |
| Cryptogenic cirrhosis | 61 | 1 (1.6%) | – |
| Primary sclerosing cholangitis | 54 | 2 (3.7%) | – |
| Non alcoholic fatty liver disease | 52 | 1 (1.9%) | – |
| Miscellaneous* | 148 | – | – |
| Controls | 679 | 12 (1.8%) | 1 (0.1%) |