Amsterdam criteria I: | |
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1 | One member diagnosed with colorectal cancer before age 50. |
2 | Two affected generations. |
3 | Three affected relatives, one of them a first degree relative of the other two. |
4 | Familial adenomatous polyposis should be excluded. |
5 | Tumours should be verified by pathological examination. |
Amsterdam criteria II: | |
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1 | There should be at least three relatives with an HNPCC-associated cancer (colorectal cancer, cancer of the endometrium, small bowel, ureter, or renal pelvis). |
2 | One should be a first degree relative of the other two. |
3 | At least two successive generations should be affected. |
4 | At least one should be diagnosed before age 50. |
5 | Familial adenomatous polyposis should be excluded in the colorectal cancer cases. |
6 | Tumours should be verified by pathological examination. |