Summary of regions with multipoint or two point LOD scores of ⩾1.18 in subgroup analysis
| Marker name | Cytogenic position (cM)* | Marker position* | Heterozygosity(%) | Multipoint data† | Two point data† | |||
|---|---|---|---|---|---|---|---|---|
| LOD | Point wise p | LOD | Point wise p | |||||
| *Marker positions are from the database of a GenethonMap in the National Center for Biotechnology Information (http://www.ncbi.nlm.nih.gov/). | ||||||||
| †Entries with an LOD score of <1.18 are in parentheses. | ||||||||
| ‡Number of sibpairs analysed. | ||||||||
| Proximal, | Chromosome 1 | |||||||
| n = 25‡ | D1S2797 | 77.6 | 1p33 | 73.8 | 1.66 | 0.0028 | (0.90) | 0.021 |
| D1S2890 | 87.7 | 1p32.2 | 76.9 | 1.60 | 0.0033 | (0.60) | 0.048 | |
| Chromosome 2 | ||||||||
| D2S364 | 186.2 | 2q31.3 | 79.9 | 2.13 | 0.00086 | 1.21 | 0.0091 | |
| D2S117 | 194.5 | 2q32.3 | 89.2 | 2.02 | 0.0012 | (1.10) | 0.012 | |
| D2S325 | 210.9 | 2q33.3 | 74.5 | 3.61 | 0.00002 | 2.93 | 0.0001 | |
| D2S2382 | 220.7 | 2q35 | 51.1 | 2.59 | 0.00028 | (0.57) | 0.053 | |
| D2S126 | 220.1 | 2q36.1 | 76.7 | 2.11 | 0.00091 | 1.60 | 0.0033 | |
| Chromosome 5 | ||||||||
| D5S407 | 64.7 | 5q11.2 | 82.8 | 1.18 | 0.0098 | (0.52) | 0.061 | |
| D5S647 | 74.7 | 5q12.3 | 82.7 | 1.57 | 0.0036 | 2.16 | 0.0008 | |
| Chromosome 8 | ||||||||
| D8S277 | 8.3 | 8p23.1 | 83.2 | 1.78 | 0.0021 | 1.24 | 0.0083 | |
| Chromosome 19 | ||||||||
| D19S884 | 26.0 | 19p13.2 | 80.0 | 1.31 | 0.0071 | 1.21 | 0.0090 | |
| D19S220 | 61.4 | 19q13.13 | 90.7 | (0.86) | 0.023 | 2.22 | 0.0007 | |
| Chromosome X | ||||||||
| DXS993 | 66.1 | Xp11.4 | 74.5 | 1.21 | 0.0092 | (0.25) | 0.14 | |
| Distal, | Chromosome 2 | |||||||
| n = 108 | D2S162 | 20.0 | 2p25.1 | 78.1 | (0.34) | 0.11 | 1.46 | 0.0048 |
| D2S325 | 204.5 | 2q33.3 | 74.5 | 1.41 | 0.0055 | 1.38 | 0.0059 | |
| Chromosome 11 | ||||||||
| D11S904 | 33.6 | 11p14.2 | 16.3 | 1.36 | 0.0061 | 1.65 | 0.0029 | |
| D11S935 | 49.6 | 11p13 | 75.5 | (0.44) | 0.077 | 1.67 | 0.0028 | |
| Diffuse, | Chromosome 11 | |||||||
| n = 76 | D11S904 | 33.6 | 11p14.2 | 16.3 | 2.12 | 0.0009 | 1.57 | 0.0035 |
| D11S935 | 45.9 | 11p13 | 75.5 | 1.45 | 0.0049 | 3.51 | 0.00003 | |
| D11S1314 | 73.6 | 11q13.4 | 74.6 | (0.81) | 0.027 | 1.37 | 0.0060 | |
| Intestinal, | Chromosome 21 | |||||||
| n = 62 | D21S1256 | 8.6 | 21q21.1 | 63.5 | 1.35 | 0.0064 | (1.16) | 0.01 |
| D21S1914 | 19.4 | 21q21.2 | 87.7 | 1.23 | 0.0087 | (1.07) | 0.013 | |
| Age at | Chromosome 2 | |||||||
| diagnosis | D2S325 | 204.5 | 2q33.3 | 74.5 | 1.96 | 0.0013 | (1.08) | 0.013 |
| <50, | D2S2382 | 220.7 | 2q35 | 51.1 | 1.59 | 0.0034 | (0.51) | 0.063 |
| n = 53 | Chromosome 21 | |||||||
| D21S1256 | 8.6 | 21q21.1 | 63.5 | 1.34 | 0.0066 | 1.31 | 0.0070 | |