The genotype and allele distribution of three SNPs in NPC patients and controls
| Polymorphism | NPC patients (n = 239) | Controls (n = 286) | OR (95% CI) | p |
|---|---|---|---|---|
| The frequencies of genotypes are indicated in absolute values and percentages in parentheses. The sums of genotypes in patients and controls do not add up to the total number of subjects, owing to failure of genotyping for some individuals. All ORs are adjusted for age and gender. | ||||
| A-3348C | ||||
| Genotype | ||||
| A/A | 9 (3.9%) | 15 (5.4%) | 1.0 | — |
| A/C | 90 (38.6%) | 116 (41.6%) | 1.3 (0.6–3.1) | 0.564 |
| C/C | 134 (57.5%) | 148 (53.0%) | 1.5 (0.6–3.6) | 0.342 |
| Allele | ||||
| A | 108 (23.2%) | 146 (26.2%) | 1.0 | — |
| C | 358 (76.8%) | 412 (73.8%) | 1.2 (0.9–1.6) | 0.273 |
| C-2128T | ||||
| Genotype | ||||
| T/T | 120 (50.2%) | 160 (56.9%) | 1.0 | — |
| T/C | 50 (20.9%) | 81 (28.8%) | 0.9 (0.6–1.4) | 0.468 |
| C/C | 69 (28.9%) | 40 (14.2%) | 2.8 (1.7–4.9) | 0.0006 |
| Allele | ||||
| T | 290 (60.7%) | 401 (71.4%) | 1.0 | — |
| C | 188 (39.3%) | 161 (28.6%) | 1.7 (1.3–2.2) | 0.0009 |
| C-1888T | ||||
| Genotype | ||||
| T/T | 64 (27.6%) | 99 (35.1%) | 1.0 | — |
| T/C | 121 (52.2%) | 163 (57.8%) | 1.2 (0.8–1.7) | 0.510 |
| C/C | 47 (20.2%) | 20 (7.1%) | 3.3 (1.8–6.1) | <0.0001 |
| Allele | ||||
| T | 249 (53.7%) | 361 (64.0%) | 1.0 | — |
| C | 215 (46.3%) | 203 (36.0%) | 1.6 (1.2–2.0) | 0.001 |