Number of individuals analysed | Number of consecutive, homozygous and concordant SNPs required to occur <1 in 1000 times by chance* | Average minimum size of the region that could be detected†‡ |
---|---|---|
*See Appendix 2 for full calculations. | ||
†Assuming a sex-averaged autosomal length of 3488 cM.8 | ||
‡For much of the genome the coverage of SNPs is fairly uniform, but there are areas of reduced coverage (see MRC Geneservice website: http://www.hgmp.mrc.ac.uk/geneservice/index.shtml), particularly where 1 cM>1 Mb and the subtelomeric regions. | ||
1 patient | 46 | 17 cM |
2 siblings | 23 | 8 cM |
3 siblings | 16 | 6 cM |
4 siblings | 12 | 4 cM |
2 unrelated | 12 | 4 cM |
2 siblings and 1 unrelated | 10 | 3.6 cM |
3 unrelated | 7 | 2.5 cM |
4 unrelated | 5 | 1.5 cM |