Distribution of MBL2 genotypes according to FEV1% in patients aged 12 to 15 years
| Structural variants | Genotype | Mean difference | 95% confidence interval | p value | |
|---|---|---|---|---|---|
| AA | AO+OO | ||||
| Mean FEV1% predicted (standard deviation) | 71.8 (22.5) | 64.8 (22.1) | 7.0 | −1.5 to 15.6 | 0.10 |
| No>70% FEV1 (%) n = 59 | 37 (62.7%) | 22 (37.3%) | 0.51 | ||
| No<70% FEV1 (%) n = 53 | 30 (56.6%) | 23 (43.4%) | |||
| No>90% FEV1 (%) n = 23 | 20 (87.0%) | 3 (13.0%) | 0.002 | ||
| No<90% FEV1 (%) n = 89 | 47 (52.8%) | 42 (47.2%) | |||
| Structural or promoter variants | High* | Low† | |||
|---|---|---|---|---|---|
| *High is AA-YY+AA-YX. | |||||
| †Low is AA-XX, AO-XX, AO-XY and OO-YY. | |||||
| Mean FEV1% predicted (standard deviation) | 72.2 (22.9) | 65.3 (22.7) | 6.9 | −1.4 to 15.3 | 0.10 |
| No>70% FEV1 (%) n = 59 | 34 (57.6%) | 25 (42.4%) | 0.36 | ||
| No<70% FEV1 (%) n = 53 | 26 (49.1%) | 27 (50.9%) | |||
| No>90% FEV1 (%) n = 23 | 18 (78.3%) | 5 (21.7%) | 0.006 | ||
| No<90% FEV1 (%) n = 89 | 42 (47.2%) | 47 (52.8%) | |||