Allele frequencies of UGT1A7 in patients with pancreatic diseases and healthy controls
| Alleles | Czech Republic | Germany | Netherlands | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ACP (n = 76) | ICP/HP (n = 110) | CO (n = 638) | ACP (n = 296) | ICP/HP (n = 272) | AP (n = 306) | PC (n = 402) | CO (n = 864) | Alc CO (n = 60) | ACP (n = 154) | ICP/HP (n = 116) | CO (n = 550) | Alc CO (n = 186) | |
| UGT1A7 | |||||||||||||
| *1 | 0.32 | 0.39 | 0.36 | 0.35 | 0.39 | 0.34 | 0.33 | 0.33 | 0.25 | 0.38 | 0.41 | 0.37 | 0.42 |
| *2 | 0.25 | 0.24 | 0.23 | 0.25 | 0.21 | 0.24 | 0.25 | 0.25 | 0.27 | 0.20 | 0.22 | 0.23 | 0.22 |
| *3 | 0.43 | 0.36 | 0.40 | 0.39 | 0.40 | 0.42 | 0.40 | 0.42 | 0.48 | 0.40 | 0.35 | 0.40 | 0.35 |
| 10 | 0.00 | 0.01 | 0.02 | 0.01 | 0.004 | 0.007 | 0.02 | 0.006 | 0.00 | 0.02 | 0.02 | 0.01 | 0.00 |
| *11 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Switzerland | All countries | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Alleles | ACP (n = 110) | ICP/HP (n = 32) | PC (n = 70) | CO (n = 766) | AC (n = 636) | ICP/HP (n = 532) | AP (n = 306) | PC (n = 472) | CO (n = 2818) | Alc CO (n = 246) | |||
| Odds ratio is given for the *3 allele v the other alleles. | |||||||||||||
| ACP, alcoholic chronic pancreatitis; Alc CO, alcoholic control subjects; AP, acute pancreatitis; CI, confidence interval; CO, healthy control subjects; ICP/HP, idiopathic chronic pancreatitis/hereditary chronic pancreatitis; OR, odds ratio adjusted for age, sex, and country of origin; PC, pancreatic adenocarcinoma. | |||||||||||||
| UGT1A7 | |||||||||||||
| *1 | 0.37 | 0.34 | 0.26 | 0.36 | 0.36 | 0.39 | 0.34 | 0.32 | 0.35 | 0.38 | |||
| *2 | 0.28 | 0.22 | 0.33 | 0.22 | 0.24 | 0.22 | 0.24 | 0.26 | 0.23 | 0.23 | |||
| *3 | 0.34 | 0.44 | 0.40 | 0.41 | 0.39 | 0.38 | 0.42 | 0.40 | 0.41 | 0.39 | |||
| 10 | 0.01 | 0.00 | 0.01 | 0.01 | 0.006 | 0.004 | 0.007 | 0.013 | 0.007 | 0.00 | |||
| *11 | 0.00 | 0.00 | 0.00 | 0.003 | 0.00 | 0.00 | 0.00 | 0.00 | 0.0004 | 0.00 | |||
| OR | 0.90 | 0.95 | 1.02 | 0.91 | 0.95 | ||||||||
| 95% CI | 0.74 to 1.10 | 0.75 to 1.20 | 0.78 to 1.34 | 0.73 to 1.13 | 0.71 to 1.29 | ||||||||