MTHFR genotypes and concentrations of plasma total homocysteine and folate, red blood cell folate, and [3H]-dCTP incorporation
| MTHFR 677C→T genotype | C/C (n = 44) | C/T (n = 43) | T/T (n = 9) |
|---|---|---|---|
| Homocysteine (μM) | 8.3 (7.9–9.2) | 9.0 (8.3–9.8) | 10.2 (8.9–12.1)* |
| Plasma folate (nM) | 16.6 (16.7–21.6) | 15.9 (13.9–20.2) | 12.5 (10.0–17.9)* |
| Red blood cell folate (nM) | 616 (520–632) | 555 (479–608) | 688 (568–933)* |
| [3H]-dCTP incorporation (103 dpm/μg DNA) | 21.8 (20.2–23.0) | 21.3 (19.8–24.0) | 26.3 (22.2–37.6)* |
| MTHFR1298A→C genotype | A/A (n = 48) | A/C (n = 41) | C/C (n = 7) |
|---|---|---|---|
| All values are expressed as median and 95% confidence intervals. | |||
| *p<0.05 for 677TT versus 677CC or for 1298CC versus 1298AA | |||
| Homocysteine (μM) | 9.1 (8.20–9.5) | 8.2 (8.1–9.5) | 10.5 (9.3–12.4)* |
| Plasma folate (nM) | 15.4 (14.9–20.6) | 16.8 (15.0–20.4) | 16.5 (13.1–19.4) |
| Red blood cell folate (nM) | 618 (546–694) | 580 (527–772) | 734 (467–890) |
| [3H]-dCTP incorporation (103 dpm/μg DNA) | 21.7 (20.3–25.0) | 21.9 (20.3–23.1) | 25.8 (22.8–27.1) |