Table 1

Two-point LOD scores between otosclerosis and the known otosclerosis loci OTSC1, OTSC2, and OTSC3

LocusMarkerRecombination fraction (θ)
0.00.010.050.10.20.30.4
OTSC1D15S652−6.67−4.68−2.88−1.88−0.80−0.27−0.04
D15S1004−5.57−4.57−2.83−1.83−0.81−0.31−0.07
D15S657−0.03−0.010.050.090.130.120.07
OTSC2D7S495−5.57−3.91−2.56−1.72−0.76−0.29−0.06
D7S2560−3.91−2.19−0.93−0.310.190.280.13
D7S684−1.48−0.130.460.640.630.420.14
D7S2513−4.36−2.86−1.84−1.19−0.44−0.100.00
D7S2426−4.04−2.51−1.40−0.87−0.38−0.15−0.04
OTSC3D6S1588−0.71−0.63−0.37−0.180.000.040.02
D6S273−1.06−0.99−0.75−0.50−0.18−0.05−0.02
D6S291−2.41−2.07−1.41−0.99−0.58−0.33−0.13
D6S1680−2.70−2.31−1.54−1.05−0.51−0.21−0.05
D6S426−4.10−3.48−2.30−1.50−0.63−0.22−0.05