Tests for interaction with APOE-4 and stratum specific genotype frequencies in unrelated cases and controls
| Marker | Test of interaction (p value) | SNP genotype | Genotype frequencies No APOE-4 | Genotype frequencies, carriers of APOE-4 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases (n = 189) | Controls (n = 619) | Cases (n = 395) | Controls (n = 239) | |||||||||
| *Significant difference in genotype frequencies between cases and controls within APOE-4 stratum (p<0.05). | ||||||||||||
| SNP3 | 0.150 | GT+TT | 0.68 | 0.69 | 0.72 | 0.64* | ||||||
| SNP4 | 0.048 | AA+AG | 0.39 | 0.43 | 0.45 | 0.32* | ||||||
| SNP6 | 0.057 | CC+CT | 0.85 | 0.87 | 0.87 | 0.80* | ||||||
| SNP8 | 0.027 | AA+AG | 0.99 | 0.95* | 0.92 | 0.95 | ||||||