Intellectual level, autistic disorder, and infantile spasms in cases with characterised TSC1 and TSC2 mutations
| Characteristic | Total number | TSC1 | TSC2 | χ2 | p |
|---|---|---|---|---|---|
| IS, infantile spasms. | |||||
| *Familial plus sporadic cases; †Sporadic cases only. | |||||
| IQ⩾70 (all cases)* | 41 | 17 (77%) | 24 (34%) | 12.5 | <0.001 |
| IQ<70 (all cases)* | 51 | 5 (23%) | 46 (66%) | ||
| IQ⩾70 (sporadics)† | 34 | 11 (69%) | 23 (36%) | 5.6 | 0.018 |
| IQ<70 (sporadics)† | 46 | 5 (31%) | 41 (64%) | ||
| No autistic disorder (all cases)* | 62 | 19 (86%) | 43 (61%) | 4.74 | 0.030 |
| Autistic disorder (all cases)* | 30 | 3 (14%) | 27 (39%) | ||
| No autistic disorder (sporadics)† | 52 | 13 (81%) | 39 (61%) | 2.32 | 0.128 |
| Autistic disorder (sporadics)† | 28 | 3 (19%) | 25 (39%) | ||
| No IS (all cases)* | 44 | 16 (84%) | 28 (42%) | 10.32 | 0.001 |
| IS (all cases)* | 41 | 3 (16%) | 38 (58%) | ||
| No IS (sporadics)† | 35 | 10 (77%) | 25 (42%) | 5.32 | 0.021 |
| IS (sporadics)† | 38 | 3 (23%) | 35 (58%) | ||